Alzheimer's Dementia and Exercise Intervention: An Umbrella Review Combining 21 Meta-Analyses

📖 Literature Information and Abstract Translation

Effects of physical activity and exercise interventions on Alzheimer’s disease: An umbrella review of existing meta-analyses

[Background/Objective] Over the past decade, physical activity (PA) (or "exercise") has been identified as one of the main modifiable factors influencing the progression of Alzheimer’s disease (AD) pathology. We conducted an umbrella review to summarize the evidence regarding the association between PA/exercise and the risk of developing AD, as well as the effects of exercise interventions on the progression of AD.

[Methods] A systematic search was conducted in PubMed, SportDiscus, Cochrane Library, and Web of Science (March 2022) to identify meta-analyses evaluating the association between PA and the incidence of AD, as well as meta-analyses evaluating the effects of exercise interventions on patients with AD.

[Results] 21 studies were included. The results with the strongest evidence revealed a positive effect of PA on AD risk. Specifically, meeting WHO recommendations for PA was associated with a reduced risk of AD. It was also revealed that exercise has positive effects on cognitive function, physical capacity, and functional independence.

[Conclusion] There is strong evidence that regular exercise prevents AD risk, but the dose-response relationship remains unclear. While exercise appears to improve several aspects of AD patients, further research is needed to clarify the exercise characteristics that promote maximum benefits.

🌱 So What?: What did I find interesting?

The world we live in seems the same, but it is not.
Each and every one of us is living in a world represented in our own brains.
Because of that mechanism, all of humanity is forced to wear colored glasses.

Living in such a world, we share truths beyond the individual.
That seems like a very difficult thing to do.
I believe that what indicates the distance to that truth is the evidence level.
With just one fact (a single study), there is a possibility that the influence of colored glasses is strong.
A review (meta-analysis) that collects many of those facts is considered to be quite close to the truth.
So, what happens if you bundle those reviews together?
I think it would be hard to call that something seen through colored glasses anymore.
You get a conclusion close to the truth.

This time, using the method called an umbrella review, the effects of exercise intervention on Alzheimer's dementia were clarified.
Helpfully for the reader, it was shown in an easy-to-understand manner using beautiful diagrams.
When explaining these effects, it might be good to add some emphasis.

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