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18 April 2017

Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis

Authors: John W. Pickering, PhD, Martin P. Than, MBBS, Louise Cullen, MBBS, PhD, Sally Aldous, MBChB, PhD, Ewoud ter Avest, MD, PhD, Richard Body, MBChB, PhD, Edward W. Carlton, MBChB, … Show All … , Paul Collinson, MBBChir, MD, Anne Marie Dupuy, MD, PhD, Ulf Ekelund, MD, PhD, Kai M. Eggers, MD, PhD, Christopher M. Florkowski, MBBS, MD, Yonathan Freund, MD, PhD, Peter George, MBBS, Steve Goodacre, MB, ChB, MSc, PhD, Jaimi H. Greenslade, PhD, Allan S. Jaffe, MD, Sarah J. Lord, MBBS, MSc, Arash Mokhtari, MD, Christian Mueller, MD, Andrew Munro, MBChB, Sebbane Mustapha, MD, PhD, William Parsonage, MBBS, DM, W. Frank Peacock, MD, Christopher Pemberton, PhD, A. Mark Richards, MD, PhD, Juan Sanchis, MD, PhD, Lukas P. Staub, MD, PhD, Richard Troughton, MBChB, PhD, Raphael Twerenbold, MD, Karin Wildi, MD, and Joanna Young, PhDAuthor, Article, & Disclosure Information

Publication: Annals of Internal Medicine

Volume 166, Number 10

https://doi.org/10.7326/M16-2562

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Abstract

This article has been corrected. The original version (PDF) is appended to this article as a Supplement.

Background:

High-sensitivity assays for cardiac troponin T (hs-cTnT) are sometimes used to rapidly rule out acute myocardial infarction (AMI).

Purpose:

To estimate the ability of a single hs-cTnT concentration below the limit of detection (<0.005 µg/L) and a nonischemic electrocardiogram (ECG) to rule out AMI in adults presenting to the emergency department (ED) with chest pain.

Data Sources:

EMBASE and MEDLINE without language restrictions (1 January 2008 to 14 December 2016).

Study Selection:

Cohort studies involving adults presenting to the ED with possible acute coronary syndrome in whom an ECG and hs-cTnT measurements were obtained and AMI outcomes adjudicated during initial hospitalization.

Data Extraction:

Investigators of studies provided data on the number of low-risk patients (no new ischemia on ECG and hs-cTnT measurements <0.005 µg/L) and the number who had AMI during hospitalization (primary outcome) or a major adverse cardiac event (MACE) or death within 30 days (secondary outcomes), by risk classification (low or not low risk). Two independent epidemiologists rated risk of bias of studies.

Data Synthesis:

Of 9241 patients in 11 cohort studies, 2825 (30.6%) were classified as low risk. Fourteen (0.5%) low-risk patients had AMI. Sensitivity of the risk classification for AMI ranged from 87.5% to 100% in individual studies. Pooled estimated sensitivity was 98.7% (95% CI, 96.6% to 99.5%). Sensitivity for 30-day MACEs ranged from 87.9% to 100%; pooled sensitivity was 98.0% (CI, 94.7% to 99.3%). No low-risk patients died.

Limitation:

Few studies, variation in timing and methods of reference standard troponin tests, and heterogeneity of risk and prevalence of AMI across studies.

Conclusion:

A single hs-cTnT concentration below the limit of detection in combination with a nonischemic ECG may successfully rule out AMI in patients presenting to EDs with possible emergency acute coronary syndrome.

Primary Funding Source:

Emergency Care Foundation.

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Supplemental Material

Supplement 1. Study Protocol

Supplement 2. Supplementary Material

Supplement. Original Version (PDF)

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Comments

0 Comments

Zhen Zhao, PhD, Matthew Greenblatt, MD, PhD, Lance Truong, MS Weill Cornell Medicine 15 October 2019

Concerns

We are writing to discuss concerns regarding a recent publication “Rapid Rule-out of Acute Myocardial Infarction with a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection, A Collaborative Meta-analysis” (Ann Intern Med. 2017 May 16;166(10):715-724). We have found important discrepancies between the data found in the manuscript and the values presented in the meta-analysis itself. This study claimed that it performed a meta-analysis of 11 cohorts using hs-cTnT below the LoD (5ng/L) and a nonischemic ECG (Figures 2 and 3). However, three of the studies did not use hs-cTnT, six studies used different cutoff values, and two studies reported different sensitivities. In short, none of the cited studies used the exact same criteria as described by the meta-analysis. We believe that these discrepancies in part reflect that the investigators are not aware of several lab medicine related issues pertaining to troponin assays. We believe that these findings have a major impact on the validity of the conclusions of this manuscript.

John W Pickering, PhD and Martin Than, MD on behalf of the study authors Emergency Department, Christchurch Hospital, Christchurch New Zealand 18 October 2019

In response:

We thank Dr Zhao and colleagues for taking an interest in our study and going to the trouble of looking up the primary references of the eleven studies. We agree that there are numerous lab medicine related issues pertaining to troponin assays that are often under-appreciated and believe that as members and contributors to the International Federation of Clinical Chemistry (IFCC) Task Force on Clinical Applications of Cardiac Biomarkers, that we have a good understanding of this issues. We believe that the queries raised are well intentioned and we are pleased to be able to respond and to highlight a number of aspects in the way our study was conducted that may have been misinterpreted by Dr Zhao and colleagues. Firstly, they are correct in that three of the studies did not use hs-cTnT to adjudicate final outcomes. These studies are identified in Supplementary Table 4 of the abstract. It is very common in the literature to see with development and validation of diagnostic algorithms that the troponin assay tested is different from the assay used to adjudicate outcomes. This, though, has no bearing on the analysis performed. Secondly, it is not accurate to suggest that the meta-analysis performed did not use the exact same criteria as described in the meta-analysis. The analysis performed is entirely based on the source data provided by the authors of each of the 11 studies of cTnT concentrations measured with the hs-cTnT assay. We believe that for a meta-analysis source data is preferable to data extracted from papers. The search criteria used (see the Study Selection criteria) merely identified studies with hs-cTnT measurement. We specifically excluded studies if, when the study investigators were contacted, they were unable or unwilling to provide source data. The data provided by the investigators of the 11 studies was in the form of 2x2 tables of hs-cTnT performance at the thresholds of 5 ng/L (LoD) and 3 ng/L (LoB) (See Supplementary Tables 6 and 7). In short, data from all of the cited studies used the exact same criteria. We believe the conclusions of the manuscript are valid. We apologize if wording in the paper has caused any confusion.

Information & Authors

Information

Published In

Annals of Internal Medicine

Volume 166 • Number 10 • 16 May 2017

Pages: 715 - 724

History

Published online: 18 April 2017

Published in issue: 16 May 2017

Keywords

Copyright

Authors

Affiliations

John W. Pickering, PhD

From Christchurch Hospital, University of Otago Christchurch, and Christchurch Heart Institute, Christchurch, New Zealand; Queensland University of Technology and Royal Brisbane and Women's Hospital, Herston, Queensland, Australia; Medical Centre Leeuwarden, Leeuwarden, the Netherlands; Central Manchester University Hospitals NHS Foundation Trust and University of Manchester, Manchester, United Kingdom; Southmead Hospital, North Bristol NHS Trust, Bristol, United Kingdom;

St. George's University Hospitals NHS Foundation Trust and St. George's University of London, London, United Kingdom; Hôpital Lapeyronie, Montpellier, France; Skåne University Hospital, Lund, Sweden; Uppsala University, Uppsala, Sweden; Sorbonne Université and Assistance Publique-Hôpitaux de Paris, Paris, France; University of Sheffield, Sheffield, United Kingdom; Mayo Clinic, Rochester, Minnesota; University of Notre Dame Australia, Darlinghurst, New South Wales, Australia;

Universitätsspital Basel, Basel, Switzerland; Nelson Hospital, Nelson, New Zealand; Baylor College of Medicine, Houston, Texas; National University of Singapore, Singapore; Universidad de Valencia, CIBERCV, Hospital Clínico Universitario, Valencia, Spain; and University of Sydney, Camperdown, New South Wales, Australia.

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Martin P. Than, MBBS

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Louise Cullen, MBBS, PhD

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Sally Aldous, MBChB, PhD

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Ewoud ter Avest, MD, PhD

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Richard Body, MBChB, PhD

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Edward W. Carlton, MBChB

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Paul Collinson, MBBChir, MD

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Anne Marie Dupuy, MD, PhD

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Ulf Ekelund, MD, PhD

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Kai M. Eggers, MD, PhD

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Christopher M. Florkowski, MBBS, MD

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Yonathan Freund, MD, PhD

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Peter George, MBBS

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Steve Goodacre, MB, ChB, MSc, PhD

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Jaimi H. Greenslade, PhD

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Allan S. Jaffe, MD

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Sarah J. Lord, MBBS, MSc

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Arash Mokhtari, MD

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Christian Mueller, MD

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Andrew Munro, MBChB

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Sebbane Mustapha, MD, PhD

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William Parsonage, MBBS, DM

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W. Frank Peacock, MD

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Christopher Pemberton, PhD

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A. Mark Richards, MD, PhD

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Juan Sanchis, MD, PhD

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Lukas P. Staub, MD, PhD

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Richard Troughton, MBChB, PhD

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Raphael Twerenbold, MD

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Karin Wildi, MD

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Joanna Young, PhD

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Acknowledgment: The authors thank Dr. Joanne Deely of JMD Writing Consultants for helping to write and edit the manuscript and the Emergency Care Foundation for helping to fund the manuscript development.

Financial Support: Dr. Pickering was supported by a Senior Research Fellowship from the Canterbury Medical Research Foundation, the Emergency Care Foundation, and the Canterbury District Health Board. Dr. Than was supported by a Clinical Practitioners Research Fellowship from the Health Research Council of New Zealand. Dr. Cullen was supported by a Research Fellowship from the Queensland Emergency Medicine Research Foundation. No commercial organization funded or was involved in this study. Roche Diagnostics provided funding for some of the cohorts included in this meta-analysis (see Table 4 of Supplement 2).

Disclosures: Dr. Pickering reports grants from the Emergency Care Foundation, Canterbury Medical Research Foundation, and Canterbury District Health Board and nonfinancial support from Roche Diagnostics during the conduct of the study. Dr. Than reports grants and other support from Abbott, Beckman Coulter, and Roche outside the submitted work. Dr. Cullen reports grants from Roche, Abbott Diagnostics, Siemens, Beckman Coulter, and Radiometer Pacific during the conduct of the study and personal fees from Abbott Diagnostics, Siemens, AstraZeneca, and Novartis outside the submitted work. Dr. Body reports a consultancy for Creavo Medical Technologies; grants from Roche Diagnostics, Abbott Point of Care, Novartis, Portola Pharmaceuticals, Boehringer Ingelheim, Shire, and FABPulous; a patent for the Manchester Acute Coronary Syndromes decision rule; and travel/accommodations/meeting expenses from Roche Diagnostics and Randox Laboratories outside the submitted work. Dr. Carlton reports a grant from Abbott Diagnostics during the conduct of the study and a grant from the Royal College of Emergency Medicine outside the submitted work. Dr. Collinson reports a grant from the U.K. Health Technology Assessment Programme before the conduct of the study. Dr. Eggers reports personal fees from Abbott Laboratories, AstraZeneca, and Fiomi Diagnostics and nonfinancial support from Abbott Laboratories outside the submitted work. Dr. Goodacre reports a grant from the U.K. National Institute for Health Research during the conduct of the study. Dr. Greenslade reports a grant from the Emergency Medicine Foundation during the conduct of the study. Dr. Jaffe reports personal fees from Roche, Abbott, Siemens, Alere, Beckman Coulter, Sphingotec, NeuroGenomeX, IL, Singulex, ET Healthcare, and Novartis during the conduct of the study. Dr. Mokhtari reports grants from Region Skåne and ALF during the conduct of the study. Dr. Mueller reports grants from several diagnostic companies during the conduct of the study and personal fees from several diagnostic companies outside the submitted work. Dr. Parsonage reports a grant from Roche Diagnostics during the conduct of the study and personal fees from Pfizer outside the submitted work. Dr. Peacock reports grants and personal fees from Abbott, Alere, and Roche outside the submitted work. Dr. Richards reports nonfinancial support from Roche Diagnostics during the conduct of the study and personal fees from Roche Diagnostics outside the submitted work. Dr. Troughton reports a grant from the Health Research Council of New Zealand during the conduct of the study. Dr. Twerenbold reports a grant from the Swiss National Science Foundation and personal fees from Roche and Abbott outside the submitted work. Dr. Young reports a postdoctoral research fellowship with The Heart Foundation. Authors not named here have disclosed no conflicts of interest. Disclosures can also be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-2562.

Editors' Disclosures: Christine Laine, MD, MPH, Editor in Chief, reports that she has no financial relationships or interests to disclose. Darren B. Taichman, MD, PhD, Executive Deputy Editor, reports that he has no financial relationships or interests to disclose. Cynthia D. Mulrow, MD, MSc, Senior Deputy Editor, reports that she has no relationships or interests to disclose. Deborah Cotton, MD, MPH, Deputy Editor, reports that she has no financial relationships or interest to disclose. Jaya K. Rao, MD, MHS, Deputy Editor, reports that she has stock holdings/options in Eli Lilly and Pfizer. Sankey V. Williams, MD, Deputy Editor, reports that he has no financial relationships or interests to disclose. Catharine B. Stack, PhD, MS, Deputy Editor for Statistics, reports that she has stock holdings in Pfizer and Johnson & Johnson.

Reproducible Research Statement: Study protocol: See Supplement 1. Statistical code: Not available. Data set: All data needed to reproduce the statistics are provided in the text and Supplement 2.

Corresponding Author: Martin Than, MBBS, Emergency Department, Christchurch Hospital, Private Bag 4710, Christchurch 8140, New Zealand; e-mail, [email protected].

Current Author Addresses: Dr. Pickering: Department of Medicine, University of Otago Christchurch, PO Box 4345, Christchurch 8140, New Zealand.

Dr. Than: Emergency Consultant, Emergency Department, Christchurch Hospital, Private Bag 4710, Christchurch 8140, New Zealand.

Drs. Cullen and Greenslade: Department of Emergency Medicine, Royal Brisbane and Women's Hospital, Butterfield Street, Herston, Queensland 4029, Australia.

Dr. Aldous: Cardiologist, Cardiology Department, Christchurch Hospital, Private Bag 4710, Christchurch 8140, New Zealand.

Dr. ter Avest: Emergency Consultant, Department of Emergency Medicine, Medical Centre Leeuwarden, Postbus 888, 8901 BR Leeuwarden, the Netherlands.

Dr. Body: Emergency Consultant, Central Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester M13 9PL, United Kingdom.

Dr. Carlton: Emergency Consultant, Emergency Department, Southmead Hospital, North Bristol NHS Trust, Southmead Road, Bristol BS10 5NB, United Kingdom.

Dr. Collinson: Consultant Chemical Pathologist and Professor of Cardiovascular Biomarkers, Departments of Clinical Blood Sciences and Cardiology, St. George's University Hospitals NHS Foundation Trust, Blackshaw Road, Tooting, London SW17 0QT, United Kingdom.

Dr. Dupuy: Physician and Biologist, Hôpital Lapeyronie, Laboratoire de Biochimie et d'Hormonologie, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier, cédex 5, France.

Dr. Ekelund: Emergency Consultant, Department of Emergency and Internal Medicine, Skåne University Hospital, Klinikgatan 15, 221 85 Lund, Sweden.

Dr. Eggers: Cardiologist, Department of Medical Sciences, Uppsala University, Box 256, 751 05 Uppsala, Sweden.

Dr. Florkowski: Clinical Biochemist and Associate Professor, Department of Pathology, University of Otago Christchurch, PO Box 4345, Christchurch 8140, New Zealand.

Dr. Freund: Emergency Department, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 75013 Paris, France.

Dr. George: Clinical Biochemist and Professor Department of Pathology, University of Otago Christchurch, PO Box 4345, Christchurch 8140, New Zealand.

Dr. Goodacre: Professor of Emergency Medicine, School of Health and Related Research, University of Sheffield, England Regent Court, Regent Street, Sheffield S1 4DA, United Kingdom.

Dr. Jaffe: Professor of Cardiology and Professor of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

Dr. Lord: Epidemiologist, Head of Epidemiology and Medical Statistics, School of Medicine, The University of Notre Dame Australia, 160 Oxford Street, Darlinghurst, New South Wales 2010, Australia.

Dr. Mokhtari: Physician, Department of Emergency and Internal Medicine, Skåne University Hospital, Klinikgatan 15, 221 85 Lund, Sweden.

Dr. Mueller: Cardiologist and Professor, Universitätsspital Basel, Kardiologie, Petersgraben 4, 4031 Basel, Switzerland.

Dr. Munro: Emergency Physician, Emergency Department, Private Bag 18, Nelson Hospital, Nelson 7042, New Zealand.

Dr. Mustapha: Emergency Consultant, Emergency Department, Hôpital Lapeyronie, Laboratoire de Biochimie et d'Hormonologie, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier, cédex 5, France.

Dr. Parsonage: Cardiologist, Cardiology Department, Royal Brisbane and Women's Hospital, Butterfield Street, Herston, Queensland 4029, Australia.

Dr. Peacock: Emergency Physician and Professor, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030.

Dr. Pemberton: Biochemist and Associate Professor, Christchurch Heart Institute, Department of Medicine, University of Otago Christchurch, PO Box 4345, Christchurch 8140, New Zealand.

Drs. Richards and Troughton: Cardiologist and Professor, Christchurch Heart Institute, Department of Medicine, University of Otago Christchurch, PO Box 4345, Christchurch 8140, New Zealand.

Dr. Sanchis: Cardiologist and Professor of Cardiology, Catedrático de Medicina (Cardiología), CIBERCV, Universidad de Valencia, Jefe de la Unidad de Hemodinámica y Cardiología intervencionista, Hospital Clínico Universitario, 46010 Valencia, Spain.

Dr. Staub: Epidemiologist, NHMRC Clinical Trials Centre, University of Sydney, Locked Bag 77, Camperdown, New South Wales 1450, Australia.

Dr. Twerenbold: Cardiologist, Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), Universitätsspital Basel, Kardiologie, Petersgraben 4, 4031 Basel, Switzerland.

Dr. Wildi: Senior Physician, Anaesthesiology and Surgical Intensive Care Unit, Universitätsspital Basel, Kardiologie, Petersgraben 4, 4031 Basel, Switzerland.

Dr. Young: Research Scientist, Emergency Department, Christchurch Hospital, Private Bag 4710, Christchurch 8140, New Zealand.

Author Contributions: Conception and design: J.W. Pickering, M.P. Than, L. Cullen, S. Aldous, R. Body, E.W. Carlton, C. Mueller, A.M. Richards.

Analysis and interpretation of the data: J.W. Pickering, M.P. Than, S. Aldous, R. Body, E.W. Carlton, A.M. Dupuy, U. Ekelund, P. George, J.H. Greenslade, A.S. Jaffe, S.J. Lord, C. Mueller, W.F. Peacock, C. Pemberton, A.M. Richards, L.P. Staub, R. Troughton.

Drafting of the article: J.W. Pickering, L. Cullen, E.W. Carlton, A.S. Jaffe, A. Munro, W. Parsonage, L.P. Staub.

Critical revision of the article for important intellectual content: J.W. Pickering, M.P. Than, L. Cullen, S. Aldous, E. ter Avest, R. Body, E.W. Carlton, P. Collinson, U. Ekelund, K.M. Eggers, C.M. Florkowski, P. George, S. Goodacre, J.H. Greenslade, S.J. Lord, A. Mokhtari, C. Mueller, S. Mustapha, W. Parsonage, W.F. Peacock, C. Pemberton, A.M. Richards, J. Sanchis, L.P. Staub, R. Troughton, R. Twerenbold, K. Wildi.

Final approval of the article: J.W. Pickering, M.P. Than, L. Cullen, S. Aldous, E. ter Avest, R. Body, E.W. Carlton, P. Collinson, A.M. Dupuy, U. Ekelund, K.M. Eggers, C.M. Florkowski, Y. Freund, P. George, S. Goodacre, J.H. Greenslade, A.S. Jaffe, S.J. Lord, A. Mokhtari, C. Mueller, A. Munro, S. Mustapha, W. Parsonage, W.F. Peacock, C. Pemberton, A.M. Richards, J. Sanchis, L.P. Staub, R. Troughton, R. Twerenbold, K. Wildi, J. Young.

Provision of study materials or patients: L. Cullen, P. Collinson, A. Mokhtari, C. Mueller, S. Mustapha, A.M. Richards, R. Troughton.

Statistical expertise: J.W. Pickering, C. Mueller.

Obtaining of funding: M.P. Than, L. Cullen, J.H. Greenslade, C. Mueller, W. Parsonage, C. Pemberton, A.M. Richards.

Administrative, technical, or logistic support: J.W. Pickering, P. George, A.S. Jaffe, C. Mueller, A.M. Richards, R. Troughton, R. Twerenbold, J. Young.

Collection and assembly of data: J.W. Pickering, L. Cullen, E. ter Avest, R. Body, E.W. Carlton, P. Collinson, A.M. Dupuy, U. Ekelund, C.M. Florkowski, Y. Freund, P. George, S. Goodacre, J.H. Greenslade, A. Mokhtari, C. Mueller, A. Munro, W. Parsonage, C. Pemberton, J. Sanchis, R. Twerenbold, K. Wildi, J. Young.

This article was published at Annals.org on 18 April 2017.

* Drs. Pickering and Than contributed equally to this work.

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John W. Pickering, Martin P. Than, Louise Cullen, et al. Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis. Ann Intern Med.2017;166:715-724. [Epub 18 April 2017]. doi:10.7326/M16-2562

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Dalia Virviciute,
Diana Zaliaduonyte,
Gintare Sakalyte

2024 Clinical practice guidelines for Acute myocardial infarction with ST segment elevation electrocardiogram

O. V. Averkov,
G. K. Harutyunyan,
D. V. Duplyakov,
E. V. Konstantinova,
N. N. Konstantinova,
R. M. Shakhnovich,
I. S. Yavelov,
A. N. Yakovlev,
S. A. Abugov,
B. G. Alekyan,
D. M. Aronov,
M. V. Arkhipov,
O. L. Barbarash,
S. A. Boytsov,
M. G. Bubnova,
T. N. Vavilova,
E. Yu. Vasilyeva,
A. S. Galyavich,
V. I. Ganyukov,
S. R. Gilyarevsky,
E. P. Golubev,
E. Z. Golukhova,
D. A. Zateyshchikov,
Yu. A. Karpov,
E. D. Kosmacheva,
Yu. M. Lopatin,
V. A. Markov,
E. V. Merkulov,
N. A. Novikova,
E. P. Panchenko,
D. V. Pevzner,
N. V. Pogosova,
D. M. Prasol,
A. V. Protopopov,
D. V. Skrypnik,
R. S. Tarasov,
S. N. Tereshchenko,
S. A. Ustyugov,
A. V. Khripun,
E. A. Tsebrovskaya,
S. V Shalaev,
E. V. Shlyakhto,
A. V Shpektor,
S. S. Yakushin

National Heart Foundation of Australia & Cardiac Society of Australia and New Zealand: Comprehensive Australian Clinical Guideline for Diagnosing and Managing Acute Coronary Syndromes 2025

David Brieger,
Louise Cullen,
Tom Briffa,
Sarah Zaman,
Ian Scott,
Cynthia Papendick,
Kimberley Bardsley,
Angus Baumann,
Alexandra (Sasha) Bennett,
Robyn A. Clark,
J. James Edelman,
Sally C. Inglis,
Lisa Kuhn,
Adam Livori,
Julie Redfern,
Hans Schneider,
Jeanine Stewart,
Liza Thomas,
Edwina Wing-Lun,
Ling Zhang,
Elaine Ho,
Stacey Matthews

Potential length of stay reductions from emergency department use of a point‐of‐care high‐sensitivity cardiac troponin assay: Pilot findings from Australia's first cardiac emergency department

Robert Meek,
Georgina Hayden,
Zhong X Lu,
Adam Damianopoulos,
Louise Cullen,
Evan Kumarakurusingham,
Pavith Pathirana,
Martin Than,
John W Pickering,
James Doery,
Alex Duong,
Diana Egerton‐Warburton

Evidence-based medicine and the cardiac troponin 99th percentile for the diagnosis of acute myocardial infarction

Peter E Hickman,
Julia M Potter,
Louise Cullen,
Kai M Eggers,
Martin Than,
John W Pickering,
William Parsonage,
Jenny Doust

Insulin-like growth factor binding protein-3 (IGFBP-3): a biomarker of coronary artery disease induced myocardial ischaemia

Jacqui A Lee,
Jessika Wise,
Sara D Raudsepp,
Louise N Paton,
Jan Powell,
Kieran Jina,
Sally Aldous,
Richard W Troughton,
Philip D Adamson,
A Mark Richards,
W Frank Peacock,
James L Januzzi,
Noah Erceg,
Luca Koechlin,
Jasper Boeddinghaus,
Pedro Lopez-Ayala,
Christian Mueller,
Martin P Than,
John W Pickering,
Chris J Pemberton,
Daniel Ketelhuth

Why is single sample rule out of non-ST elevation myocardial infarction using high-sensitivity cardiac troponin T safe when analytical imprecision is so high? A joint statistical and clinical demonstration

James Daniel Hatherley,
Guy Miller,
Paul Collinson,
Eduard Shantsila,
Hannah Fearon,
Angela Lambert,
Yusuf Khand,
Aleem Khand

Type 2 myocardial infarction: challenges in diagnosis and treatment

Andrew R Chapman,
Caelan Taggart,
Jasper Boeddinghaus,
Nicholas L Mills,
Keith A A Fox

Protective Effect of Carbon Dots Derived from Salvia miltiorrhiza Pretreatment in Acute Myocardial Infarction in Rats

Liyang Dong,
Menghan Li,
Tianyou Cao,
Yafang Zhao,
Shuxian Wang,
Peng Zou,
Yue Zhang,
Huihua Qu,
Yan Zhao,
Hui Kong

Sex and race disparities in emergency department patients with chest pain and a detectable or mildly elevated troponin

Lucas M. Boyer,
Anna C. Snavely,
Jason P. Stopyra,
Subha V. Raman,
Jeffrey M. Caterino,
Carol L. Clark,
Alan E. Jones,
Michael E. Hall,
Carolyn J. Park,
Brian C. Hiestand,
Sujethra Vasu,
Michael A. Kutcher,
W. Gregory Hundley,
Simon A. Mahler,
Chadwick D. Miller

Biochemical Markers of Acute Coronary Syndromes

Li Liu,
Jing Cao

How Close Are We to Patient-Side Troponin Testing?

Aaron Goldberg,
Samuel McGrath,
Michael Marber

Single high-sensitivity troponin-I for ruling out acute coronary syndrome: a detection limit approach

Siobhan Hickling,
Chelsea J Francis,
Derek P Chew,
Biswadev Mitra,
Graham S Hillis,
Magnus Bäck

Effectiveness and Safety of the ESC‐TROP (European Society of Cardiology 0h/1h Troponin Rule‐Out Protocol) Trial

Arash Mokhtari,
Jakob Lundager Forberg,
Jenny Sandgren,
Caroline Hård af Segerstad,
Catarina Ellehuus,
Ulf Ekström,
Jonas Björk,
Bertil Lindahl,
Ardavan Khoshnood,
Ulf Ekelund

Diagnostic accuracy of a machine learning algorithm using point-of-care high-sensitivity cardiac troponin I for rapid rule-out of myocardial infarction: a retrospective study

Betül Toprak,
Hugo Solleder,
Eleonora Di Carluccio,
Jaimi H Greenslade,
William A Parsonage,
Karen Schulz,
Louise Cullen,
Fred S Apple,
Andreas Ziegler,
Stefan Blankenberg,
Laura Stephensen,
Emily Brownlee,
Ellyse McCormick,
Gavin Fincher,
Emma J. Hall,
Rebecca Hancock,
Niranjan Gaikwad,
Vinay Gangathimmaiah,
Christian Hamilton-Craig,
Andrew Hobbins-King,
Gerben Keijzers,
Maryam Khorramshahi Bayat,
Ehsan Mahmoodi,
Siegfried Perez,
Isuru Ranasinghe,
Andrew Staib,
Anna Zournazi,
Martin Than

External Validation of the Recalibrated HEART Score for Evaluation of Possible Acute Coronary Syndrome

Edward Hyun Suh,
Bryn E. Mumma,
Andrew J. Einstein,
Betty C. Chang,
Phong Anh Huynh,
LeRoy E. Rabbani,
Lauren S. Ranard,
Dana L. Sacco,
Aleksandr M. Tichter,
Marc A. Probst

Adoption of high-sensitivity cardiac troponin for risk stratification of patients with suspected myocardial infarction: a multicentre cohort study

Michael McDermott,
Dorien M. Kimenai,
Atul Anand,
Zengyi Huang,
Andrew Houston,
Sophie Williams,
Felicity Evison,
Suzy Gallier,
Catalina Carenzo,
Ben Glampson,
Madina Hasan,
Alexander Robertson,
Thomas Phillips,
Cai Davis,
Elizabeth Sapey,
Erik Mayer,
Suzanne Mason,
Matthew Stammers,
Nicholas L. Mills

Determination of Clinically Acceptable Analytical Variation of Cardiac Troponin at Decision Thresholds

John W Pickering,
Peter Kavsak,
Robert H Christenson,
Richard W Troughton,
Christopher J Pemberton,
A Mark Richards,
Laura Joyce,
Martin P Than

Direct Comparison of the European Society of Cardiology 0/1-Hour Vs. 0/2-Hour Algorithms in Patients with Acute Chest Pain

Agnes Engström,
Arash Mokhtari,
Ulf Ekelund

Accelerated diagnostic protocols using high-sensitivity troponin assays to rule in or out myocardial infarction: A systematic review

Jonie J. Hsiao,
Manuel A. Celedon,
James L. Rudolph,
Kristin J. Konnyu,
Sebhat A. Erqou,
Muhammad Baig,
Thomas A. Trikalinos,
Kyari Sumayin Ngamdu,
Ghid Kanaan,
Sunny Cui,
Thien Phuc Tran,
Taylor Rickard,
Ethan M. Balk,
Eric Jutkowitz

Protocol for Improving Care by FAster risk-STratification through use of high sensitivity point-of-care troponin in patients presenting with possible acute coronary syndrome in the EmeRgency department (ICare-FASTER): a stepped-wedge cluster randomised quality improvement initiative

John W Pickering,
Gerard Devlin,
Richard Body,
Sally Aldous,
Allan S Jaffe,
Fred S Apple,
Nicholas Mills,
Richard W Troughton,
Peter Kavsak,
W Frank Peacock,
Louise Cullen,
Sarah J Lord,
Christian Müller,
Laura Joyce,
Chris Frampton,
Cameron James Lacey,
Arthur M Richards,
Suzanne Pitama,
Martin Than

Derivation and Validation of Thresholds Using Synthetic Data Methods for Single-Test Screening of Emergency Department Patients with Possible Acute Myocardial Infarction Using a Point-of-Care Troponin Assay

John W Pickering,
Joanna M Young,
Peter M George,
Antony S Watson,
Sally J Aldous,
Toby Verryt,
Richard W Troughton,
Christopher J Pemberton,
A Mark Richards,
Louise A Cullen,
Fred S Apple,
Martin P Than

Implementation of high sensitivity troponin into routine clinical practice - results of the extended CARdiac MArkers guideline uptake in Europe group (CARMAGUE) survey

Paul Collinson,
Angelika Hammerer-Lercher,
Kristin M Aakre,
Damien Gruson,
Janne Suvisaari,
Kari Pulkki,
Sanja Stankovic,
Hansjorg Baum,
Matthew T. Lowry,
Nicholas L Mills,
Paivi Laitinen

Uniform or Sex-Specific Cardiac Troponin Thresholds to Rule Out Myocardial Infarction at Presentation

Ziwen Li,
Ryan Wereski,
Atul Anand,
Matthew T.H. Lowry,
Dimitrios Doudesis,
Michael McDermott,
Amy V. Ferry,
Chris Tuck,
Andrew R. Chapman,
Kuan Ken Lee,
Anoop S.V. Shah,
Nicholas L. Mills,
Dorien M. Kimenai,
Nicholas L. Mills,
Fiona E. Strachan,
Christopher Tuck,
Atul Anand,
Olawale Mathias Akinlade,
Stephanie Barker,
Jennifer Blades,
Jasper Boeddinghaus,
Anda Bularga,
Marie de Bakker,
Andrew R. Chapman,
Dimitrios Doudesis,
Amy V. Ferry,
Takeshi Fujisawa,
Konstantin Georgiev,
Dorien M. Kimenai,
Kuan Ken Lee,
Iona Lyell,
Ziwen Li,
Matthew TH. Lowry,
Lynn McKinlay,
Michael McDermott,
Jean McPherson,
Filip Mendusic,
Andrew Sorbie,
Grace Souter,
Stacey D. Schulberg,
Caelan Taggart,
Alexander JF. Thurston,
Yong Yong Tew,
Daniel Perez-Vicencio,
Yiqing Wang,
Ryan Wereski,
Kelly Williams,
David E. Newby,
Keith AA. Fox,
Colin Berry,
Simon Walker,
Christopher J. Weir,
Ian Ford,
Alasdair Gray,
Paul O. Collinson,
Fred S. Apple,
Alan Reid,
Anne Cruikshank,
Iain Findlay,
Shannon Amoils,
David A. McAllister,
Donogh Maguire,
Jennifer Stevens,
John Norrie,
Anoop SV. Shah,
Jack PM. Andrews,
Philip D. Adamson,
Alastair Moss,
Mohamed S. Anwar,
John Hung,
Jonathan Malo,
Colin M. Fischbacher,
Bernard L. Croal,
Stephen J. Leslie,
Catriona Keerie,
Richard A. Parker,
Allan Walker,
Ronnie Harkess,
Tony Wackett,
Christopher Weir,
Roma Armstrong,
Laura Stirling,
Claire MacDonald,
Imran Sadat,
Frank Finlay,
Kathy Harrison,
Pamela Linksted,
Stephen Lavenberg

External validation of a rapid algorithm using high-sensitivity troponin assay results for evaluating patients with suspected acute myocardial infarction

Louise Cullen,
Jaimi H Greenslade,
Laura Stephensen,
Isuru Ranasinghe,
Niranjan Gaikwad,
Maryam Khorramshahi Bayat,
Ehsan Mahmoodi,
Martin Than,
Fred Apple,
William Parsonage

Serial troponin-I and long-term outcomes in subjects with suspected acute coronary syndrome

Manan Pareek,
Anna Meta Dyrvig Kristensen,
Muthiah Vaduganathan,
Christina Byrne,
Tor Biering-Sørensen,
Mats Christian Højbjerg Lassen,
Niklas Dyrby Johansen,
Kristoffer Grundtvig Skaarup,
Victoria Rosberg,
Jannik L Pallisgaard,
Martin Bødtker Mortensen,
Michael Maeng,
Christoffer B Polcwiartek,
Julia Frangeskos,
Cian P McCarthy,
Anders Nissen Bonde,
Christina Ji-Young Lee,
Emil L Fosbøl,
Lars Køber,
Niels Thue Olsen,
Gunnar H Gislason,
Christian Torp-Pedersen,
Deepak L Bhatt,
Kristian H Kragholm

Coronary computed tomography angiography versus functional stress imaging to triage chest pain in the emergency room?

Colin Berry

Troponin thresholds for myocardial infarction risk stratification

John W. Pickering

2023 ESC Guidelines for the management of acute coronary syndromes

Robert A Byrne,
Xavier Rossello,
J J Coughlan,
Emanuele Barbato,
Colin Berry,
Alaide Chieffo,
Marc J Claeys,
Gheorghe-Andrei Dan,
Marc R Dweck,
Mary Galbraith,
Martine Gilard,
Lynne Hinterbuchner,
Ewa A Jankowska,
Peter Jüni,
Takeshi Kimura,
Vijay Kunadian,
Margret Leosdottir,
Roberto Lorusso,
Roberto F E Pedretti,
Angelos G Rigopoulos,
Maria Rubini Gimenez,
Holger Thiele,
Pascal Vranckx,
Sven Wassmann,
Nanette Kass Wenger,
Borja Ibanez,
Sigrun Halvorsen,
Stefan James,
Magdy Abdelhamid,
Victor Aboyans,
Nina Ajmone Marsan,
Sotiris Antoniou,
Riccardo Asteggiano,
Maria Bäck,
Davide Capodanno,
Ruben Casado-Arroyo,
Salvatore Cassese,
Jelena Čelutkienė,
Maja Cikes,
Jean-Philippe Collet,
Gregory Ducrocq,
Volkmar Falk,
Laurent Fauchier,
Tobias Geisler,
Diana A Gorog,
Lene Holmvang,
Tiny Jaarsma,
Hywel Wynne Jones,
Lars Køber,
Konstantinos C Koskinas,
Dipak Kotecha,
Konstantin A Krychtiuk,
Ulf Landmesser,
George Lazaros,
Basil S Lewis,
Bertil Lindahl,
Ales Linhart,
Maja-Lisa Løchen,
Mamas A Mamas,
John William McEvoy,
Borislava Mihaylova,
Richard Mindham,
Christian Mueller,
Lis Neubeck,
Josef Niebauer,
Jens Cosedis Nielsen,
Alexander Niessner,
Valeria Paradies,
Agnes A Pasquet,
Steffen E Petersen,
Eva Prescott,
Amina Rakisheva,
Bianca Rocca,
Giuseppe M C Rosano,
Leyla Elif Sade,
François Schiele,
Jolanta M Siller-Matula,
Christian Sticherling,
Robert F Storey,
Matthias Thielmann,
Christiaan Vrints,
Stephan Windecker,
Rune Wiseth,
Adam Witkowski,
Mohammed El Amine Bouzid,
Hamlet Hayrapetyan,
Bernhard Metzler,
Patrizio Lancellotti,
Mugdim Bajrić,
Kiril Karamfiloff,
Andreas Mitsis,
Petr Ostadal,
Rikke Sørensen,
Tamer Elwasify,
Toomas Marandi,
Essi Ryödi,
Jean-Philippe Collet,
Archil Chukhrukidze,
Julinda Mehilli,
Periklis Davlouros,
Dávid Becker,
Ingibjörg Jóna Guðmundsdóttir,
James Crowley,
Yigal Abramowitz,
Ciro Indolfi,
Orazbek Sakhov,
Shpend Elezi,
Medet Beishenkulov,
Andrejs Erglis,
Nicolas Moussallem,
Hisham Benlamin,
Olivija Dobilienė,
Philippe Degrell,
Matthew Mercieca Balbi,
Aurel Grosu,
Zouhair Lakhal,
Jurriën ten Berg,
Hristo Pejkov,
Kristin Angel,
Adam Witkowski,
Manuel De Sousa Almeida,
Ovidiu Chioncel,
Luca Bertelli,
Sinisa Stojkovic,
Martin Studenčan,
Peter Radšel,
Jose Luis Ferreiro,
Annica Ravn-Fischer,
Lorenz Räber,
Mohammed Yassin Bani Marjeh,
Majed Hassine,
Aylin Yildirir,
Alexander Parkhomenko,
Adrian Paul Banning,
Eva Prescott,
Stefan James,
Elena Arbelo,
Colin Baigent,
Michael A Borger,
Sergio Buccheri,
Borja Ibanez,
Lars Køber,
Konstantinos C Koskinas,
John William McEvoy,
Borislava Mihaylova,
Richard Mindham,
Lis Neubeck,
Jens Cosedis Nielsen,
Agnes A Pasquet,
Amina Rakisheva,
Bianca Rocca,
Xavier Rossello,
Ilonca Vaartjes,
Christiaan Vrints,
Adam Witkowski,
Katja Zeppenfeld

Establishing optimal cutoff values for high-sensitivity cardiac troponin algorithms in risk stratification of acute myocardial infarction

Li Liu,
Kent Lewandrowski

Troponin I Biomarker Sensing Using Molecularly Imprinted Polymer Nanoparticles for Advancing Healthcare Approaches in Cardiovascular Disease

Joshua Saczek,
Oliver Jamieson,
Jake McClements,
Amy Dann,
Rhiannon E. Johnson,
Alexander D. Stokes,
Robert D. Crapnell,
Craig Banks,
Francesco Canfarotta,
Ioakim Spyridopoulos,
Alan Thomson,
Azfar Zaman,
Katarina Novakovic,
Marloes Peeters

Chest Pain Risk Stratification in the Emergency Department: Current Perspectives

Zeynep Yukselen,
Vidit Majmundar,
Mahati Dasari,
Pramukh Arun Kumar,
Yuvaraj Singh

How to Approach Patients with Acute Chest Pain

Kenji Inoue,
Tohru Minamino

Implementation of the European Society of Cardiology 0/3-hour accelerated diagnostic protocol, using high sensitive troponin T: a clinical practice evaluation of safety and effectiveness involving 3003 patients with suspected acute coronary syndrome

James Daniel Hatherley,
Thomas Salmon,
Paul O Collinson,
Aleem Khand

Trends in acute myocardial infarction mortality in the European Union, 2012–2020

Marco Zuin,
Gianluca Rigatelli,
Pierluigi Temporelli,
Stefania Angela Di Fusco,
Furio Colivicchi,
Giampaolo Pasquetto,
Claudio Bilato

Methods of the ivota triAl of he Atellica VTLi point of care emergenc de artment high sensitivity troponin eval ation

W. Frank Peacock,
James L. Januzzi,
Femke de Theije,
Taylor Briseno,
Gary Headden,
Robert Birkhahn,
Brandon R. Allen,
Simon A. Mahler

Outcomes and Management When Using High-sensitivity Versus Conventional Cardiac Troponin in Patients With Chest Pain: A Meta-analysis

John Christopher A. Pilapil,
Paula Victoria Catherine Y. Cheng,
Paul Anthony O. Alad,
Jaime Alfonso M. Aherrera

2023 ESC Guidelines for the management of acute coronary syndromes

Robert A Byrne,
Xavier Rossello,
J J Coughlan,
Emanuele Barbato,
Colin Berry,
Alaide Chieffo,
Marc J Claeys,
Gheorghe-Andrei Dan,
Marc R Dweck,
Mary Galbraith,
Martine Gilard,
Lynne Hinterbuchner,
Ewa A Jankowska,
Peter Jüni,
Takeshi Kimura,
Vijay Kunadian,
Margret Leosdottir,
Roberto Lorusso,
Roberto F E Pedretti,
Angelos G Rigopoulos,
Maria Rubini Gimenez,
Holger Thiele,
Pascal Vranckx,
Sven Wassmann,
Nanette Kass Wenger,
Borja Ibanez,
Sigrun Halvorsen,
Stefan James,
Magdy Abdelhamid,
Victor Aboyans,
Nina Ajmone Marsan,
Sotiris Antoniou,
Riccardo Asteggiano,
Maria Bäck,
Davide Capodanno,
Ruben Casado-Arroyo,
Salvatore Cassese,
Jelena Čelutkienė,
Maja Cikes,
Jean-Philippe Collet,
Gregory Ducrocq,
Volkmar Falk,
Laurent Fauchier,
Tobias Geisler,
Diana A Gorog,
Lene Holmvang,
Tiny Jaarsma,
Hywel Wynne Jones,
Lars Køber,
Konstantinos C Koskinas,
Dipak Kotecha,
Konstantin A Krychtiuk,
Ulf Landmesser,
George Lazaros,
Basil S Lewis,
Bertil Lindahl,
Ales Linhart,
Maja-Lisa Løchen,
Mamas A Mamas,
John William McEvoy,
Borislava Mihaylova,
Richard Mindham,
Christian Mueller,
Lis Neubeck,
Josef Niebauer,
Jens Cosedis Nielsen,
Alexander Niessner,
Valeria Paradies,
Agnes A Pasquet,
Steffen E Petersen,
Eva Prescott,
Amina Rakisheva,
Bianca Rocca,
Giuseppe M C Rosano,
Leyla Elif Sade,
François Schiele,
Jolanta M Siller-Matula,
Christian Sticherling,
Robert F Storey,
Matthias Thielmann,
Christiaan Vrints,
Stephan Windecker,
Rune Wiseth,
Adam Witkowski,
Mohammed El Amine Bouzid,
Hamlet Hayrapetyan,
Bernhard Metzler,
Patrizio Lancellotti,
Mugdim Bajrić,
Kiril Karamfiloff,
Andreas Mitsis,
Petr Ostadal,
Rikke Sørensen,
Tamer Elwasify,
Toomas Marandi,
Essi Ryödi,
Jean-Philippe Collet,
Archil Chukhrukidze,
Julinda Mehilli,
Periklis Davlouros,
Dávid Becker,
Ingibjörg Jóna Guðmundsdóttir,
James Crowley,
Yigal Abramowitz,
Ciro Indolfi,
Orazbek Sakhov,
Shpend Elezi,
Medet Beishenkulov,
Andrejs Erglis,
Nicolas Moussallem,
Hisham Benlamin,
Olivija Dobilienė,
Philippe Degrell,
Matthew Mercieca Balbi,
Aurel Grosu,
Zouhair Lakhal,
Jurriën ten Berg,
Hristo Pejkov,
Kristin Angel,
Adam Witkowski,
Manuel De Sousa Almeida,
Ovidiu Chioncel,
Luca Bertelli,
Sinisa Stojkovic,
Martin Studenčan,
Peter Radšel,
Jose Luis Ferreiro,
Annica Ravn-Fischer,
Lorenz Räber,
Mohammed Yassin Bani Marjeh,
Majed Hassine,
Aylin Yildirir,
Alexander Parkhomenko,
Adrian Paul Banning,
Eva Prescott,
Stefan James,
Elena Arbelo,
Colin Baigent,
Michael A Borger,
Sergio Buccheri,
Borja Ibanez,
Lars Køber,
Konstantinos C Koskinas,
John William McEvoy,
Borislava Mihaylova,
Richard Mindham,
Lis Neubeck,
Jens Cosedis Nielsen,
Agnes A Pasquet,
Amina Rakisheva,
Bianca Rocca,
Xavier Rossello,
Ilonca Vaartjes,
Christiaan Vrints,
Adam Witkowski,
Katja Zeppenfeld

Frequency, compliance, and yield of cardiac testing after high-sensitivity troponin accelerated diagnostic protocol implementation

Christopher W. Baugh,
Ron Blankstein,
Ishani Ganguli,
James L. Januzzi,
David A. Morrow,
Joshua W. Joseph,
Claire Jordan,
Gabrielle Donohoe,
Jordyn Fofi,
Katie McKinley,
Mahyar Heydarpour,
Benjamin M. Scirica,
Marcelo F. DiCarli,
John T. Nagurney

Strategies to mitigate emergency department crowding and its impact on cardiovascular patients

Christopher W Baugh,
Yonathan Freund,
Philippe Gabriel Steg,
Richard Body,
David J Maron,
Maame Yaa A B Yiadom

Clinical performance of 0/1 h cardiac troponin algorithm for diagnosing non–STEMI in an emergency setting

Qiling Gou,
Linyuan Liang,
Danping Liu,
Jia Jia,
Mengya Dong,
Haichao Chen,
Xiling Shou

Troponin in early presenters to rule out myocardial infarction

Matthew T H Lowry,
Dimitrios Doudesis,
Jasper Boeddinghaus,
Dorien M Kimenai,
Anda Bularga,
Caelan Taggart,
Ryan Wereski,
Amy V Ferry,
Stacey D Stewart,
Christopher Tuck,
Luca Koechlin,
Thomas Nestelberger,
Pedro Lopez-Ayala,
Gabrielle Huré,
Kuan Ken Lee,
Andrew R Chapman,
David E Newby,
Atul Anand,
Paul O Collinson,
Christian Mueller,
Nicholas L Mills,
Nicholas L Mills,
Fiona E Strachan,
Christopher Tuck,
Atul Anand,
Stephanie Barker,
Jennifer Blades,
Jasper Boeddinghaus,
Anda Bularga,
Andrew R Chapman,
Dimitrios Doudesis,
Amy V Ferry,
Takeshi Fujisawa,
Konstantin Georgiev,
Dorien M Kimenai,
Kuan Ken Lee,
Ziwen Li,
Matthew T H Lowry,
Lynn McKinlay,
Michael McDermott,
Jean McPherson,
Filip Mendusic,
Nicholas L Mills,
Andrew Sorbie,
Grace Souter,
Stacey D Schulberg,
Caelan Taggart,
Christopher Tuck,
Daniel Perez-Vicencio,
Yiqing Wang,
Ryan Wereski,
Kelly Williams,
Nicholas L Mills,
David E Newby,
Keith A A Fox,
Colin Berry,
Simon Walker,
Christopher J Weir,
Ian Ford,
Nicholas L Mills,
David E Newby,
Alasdair Gray,
Keith A A Fox,
Colin Berry,
Simon Walker,
Paul O Collinson,
Fred S Apple,
Alan Reid,
Anne Cruikshank,
Iain Findlay,
Shannon Amoils,
David A McAllister,
Donogh Maguire,
Jennifer Stevens,
John Norrie,
Christopher J Weir,
Anoop S V Shah,
Atul Anand,
Andrew R Chapman,
Kuan Ken Lee,
Jack P M Andrews,
Philip D Adamson,
Alastair Moss,
Mohamed S Anwar,
John Hung,
Nicholas L Mills,
Simon Walker,
Jonathan Malo,
Alan Reid,
Anne Cruikshank,
Paul O Collinson,
Colin M Fischbacher,
Bernard L Croal,
Stephen J Leslie,
Catriona Keerie,
Richard A Parker,
Allan Walker,
Ronnie Harkess,
Christopher Tuck,
Tony Wackett,
Christopher Weir,
Roma Armstrong,
Laura Stirling,
Claire MacDonald,
Imran Sadat,
Frank Finlay,
Kathy Harrison,
Atul Anand,
Pamela Linksted,
Stephen Lavenberg

Adropin – A new player in energy regulation predicts long-term prognosis of patients with acute myocardial infarction

Xiansong Chang,
Fulu Jin,
Li Wang,
Yufeng Jiang,
Peiyu Wang,
Junyan Liu,
Liangping Zhao

Single Troponin Measurement to Rule Out Myocardial Infarction

Allan S. Jaffe,
Richard Body,
Nicholas L. Mills,
Kristin M. Aakre,
Paul O. Collinson,
Amy Saenger,
Ole Hammarsten,
Ryan Wereski,
Torbjørn Omland,
Yader Sandoval,
Jordi Ordonez-Llanos,
Fred S. Apple

Implementation of high-sensitivity troponin with a rapid diagnostic algorithm reduces emergency department length of stay for discharged patients

Andrew E.O. Hughes,
Arthur Forbriger,
Adam M. May,
Mitchell G. Scott,
Douglas Char,
Christopher W. Farnsworth

Implementation of the ESC 0 h/1 h high-sensitivity troponin algorithm for decision-making in the emergency department

Maria Rubini Gimenez,
Jasper Boeddinghaus,
Thomas Nestelberger,
Luca Koechlin,
Pedro López-Ayala,
Christian Müller

Aplicación del algoritmo 0 h/1 h de troponina de alta sensibilidad de la ESC para la toma de decisiones en el servicio de urgencias

Maria Rubini Gimenez,
Jasper Boeddinghaus,
Thomas Nestelberger,
Luca Koechlin,
Pedro López-Ayala,
Christian Müller

Ruling out acute coronary syndrome in primary care with a clinical decision rule and a capillary, high-sensitive troponin I point of care test: study protocol of a diagnostic RCT in the Netherlands (POB HELP)

Simone van den Bulk,
Annelieke H J Petrus,
Robert T A Willemsen,
Mark J Boogers,
Joan G Meeder,
Braim M Rahel,
M Elske van den Akker-van Marle,
Mattijs E Numans,
Geert-Jan Dinant,
Tobias N Bonten

Surfactant-regulated acetylpyrene assemblies as fluorescent probes for identifying heme proteins in an aqueous solution

Binbin Yuan,
Shuangshuang Long,
Huamin Wang,
Qing Luo,
Ke Zeng,
Shuqin Gao,
Yingwu Lin

New Insight in Cardiorenal Syndrome: From Biomarkers to Therapy

Giovanna Gallo,
Oreste Lanza,
Carmine Savoia

Serial troponin-T and long-term outcomes in suspected acute coronary syndrome

Manan Pareek,
Kristian H Kragholm,
Anna Meta Dyrvig Kristensen,
Muthiah Vaduganathan,
Jannik L Pallisgaard,
Christina Byrne,
Tor Biering-Sørensen,
Christina Ji-Young Lee,
Anders Nissen Bonde,
Martin Bødtker Mortensen,
Michael Maeng,
Emil L Fosbøl,
Lars Køber,
Niels Thue Olsen,
Gunnar H Gislason,
Deepak L Bhatt,
Christian Torp-Pedersen

Rapid diagnostic strategies using high sensitivity troponin assays: what is the evidence and how should they be implemented?

Paul Collinson,
Ahmed Dakshi,
Aleem Khand

Evaluation of the Practice Guideline Used for Rule-Out of Myocardial Infarction at a Tertiary Cardiology Center

Reza Sheikh Sharbafan,
Hossein Farrokhpour,
Mohammad Keykhaei,
Sina Rashedi,
Roham Foroumadi,
Mehdi Mehrani,
Masih Tajdini

High sensitivity troponin - Six hours is the magic number

Rahul G. Bhat,
Michael V. Nguyen,
Omoyemen Blue,
Huyen-Trang Thai,
Maria Cacciapuoti,
Hayley Harvey,
Rory Spiegel

High Sensitivity Troponins

Tyler Thomas Hempel,
Amy Wyatt

2022 ACC Expert Consensus Decision Pathway on the Evaluation and Disposition of Acute Chest Pain in the Emergency Department

Michael C. Kontos,
James A. de Lemos,
Steven B. Deitelzweig,
Deborah B. Diercks,
M. Odette Gore,
Erik P. Hess,
Cian P. McCarthy,
James K. McCord,
Paul I. Musey,
Todd C. Villines,
Leesa J. Wright

Serial high-sensitivity cardiac troponin testing for the diagnosis of myocardial infarction: a scoping review

Hirotaka Ohtake,
Teruhiko Terasawa,
Zhivko Zhelev,
Mitsunaga Iwata,
Morwenna Rogers,
Jaime L Peters,
Chris Hyde

Point-of-care testing with high-sensitivity cardiac troponin assays: the challenges and opportunities

Louise Cullen,
Paul O Collinson,
Evangelos Giannitsis

High-Sensitivity Cardiac Troponin and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guidelines for the Evaluation and Diagnosis of Acute Chest Pain

Yader Sandoval,
Fred S. Apple,
Simon A. Mahler,
Richard Body,
Paul O. Collinson,
Allan S. Jaffe

Value of single troponin values in the emergency department for excluding acute myocardial infarction in Aboriginal and Torres Strait Islander people

Jaimi H Greenslade,
Sara Berndt,
Laura Stephensen,
Katrina Starmer,
Greg Starmer,
William Parsonage,
Victor Lau,
Tileah Drahm‐Butler,
Tania Davis,
Virginia Campbell,
Richard Stone,
Robert Bonnin,
Sarah Ashover,
Tanya Milburn,
Elizabeth Mowatt,
Karlie Proctor,
Anthony Brazzale,
Louise Ann Cullen

Identifying low-risk chest pain in the emergency department without troponin testing: a validation study of the HE-MACS and HEAR risk scores

Fraser Todd,
James Duff,
Edward Carlton

Unscheduled care pathways in patients with myocardial infarction in Scotland

Peter Hodgins,
Megan McMinn,
Anoop Shah,
Matthew J Reed,
Stewart Mercer,
Bruce Guthrie

Rapid Exclusion of Acute Myocardial Injury and Infarction With a Single High-Sensitivity Cardiac Troponin T in the Emergency Department: A Multicenter United States Evaluation

Yader Sandoval,
Bradley R. Lewis,
Ramila A. Mehta,
Olatunde Ola,
Jonathan D. Knott,
Laura De Michieli,
Ashok Akula,
Ronstan Lobo,
Eric H. Yang,
S. Michael Gharacholou,
Marshall Dworak,
Erika Crockford,
Nicholas Rastas,
Eric Grube,
Swetha Karturi,
Scott Wohlrab,
David O. Hodge,
Tahir Tak,
Charles Cagin,
Rajiv Gulati,
Allan S. Jaffe

Non‐ST‐Segment Elevation Acute Coronary Syndrome

Chest Pain, Dyspnea, Palpitations

0/2 h-Algorithm for Rapid Triage of Suspected Myocardial Infarction Using a Novel High-Sensitivity Cardiac Troponin I Assay

Karin Wildi,
Jasper Boeddinghaus,
Thomas Nestelberger,
Pedro Lopez-Ayala,
Ana Yufera Sanchez,
Bernhard Okamura,
Samyut Shrestha,
Jennifer Rohner,
Òscar Miró,
Gemma Martinez-Nadal,
F Javier Martin-Sanchez,
Luca Koechlin,
Raphael Twerenbold,
Michael Christ,
Damian Kawecki,
Maria Rubini Giménez,
Dagmar I Keller,
Christian Mueller,
Desiree Wussler,
Ivo Strebel,
Adam Bakula,
Simon Frey,
Danielle M Gualandro,
Tobias Zimmermann,
Christian Puelacher,
Jeanne du Fay de Lavallaz,
Eliska Potlukova,
Matthias Diebold,
Nicolas Geigy,
Katharina Rentsch,
Sandra Mitrovic,
Carolina Fuenzalida,
Noemi Glarner,
Beata Morawiec,
Tobias Breidthardt,
Michael Freese,
Beatriz López,
Sofia Calderón,
Esther Rodriguez Adrada,
Eva Ganovská,
Jiri Parenica,
Arnold von Eckardstein,
Isabel Campodarve,
Joaquim Gea

Diagnostic Performance of Novel Troponin Algorithms for the Rule-Out of Non-ST-Elevation Acute Coronary Syndrome

Hilde L Tjora,
Ole-Thomas Steiro,
Jørund Langørgen,
Rune O Bjørneklett,
Øyvind Skadberg,
Vernon V S Bonarjee,
Øistein R Mjelva,
Paul Collinson,
Torbjørn Omland,
Kjell Vikenes,
Kristin M Aakre

Performance of the European Society of Cardiology 0/1-Hour, 0/2-Hour, and 0/3-Hour Algorithms for Rapid Triage of Acute Myocardial Infarction An International Collaborative Meta-analysis

2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain

Martha Gulati,
Phillip D. Levy,
Debabrata Mukherjee,
Ezra Amsterdam,
Deepak L. Bhatt,
Kim K. Birtcher,
Ron Blankstein,
Jack Boyd,
Renee P. Bullock-Palmer,
Theresa Conejo,
Deborah B. Diercks,
Federico Gentile,
John P. Greenwood,
Erik P. Hess,
Steven M. Hollenberg,
Wael A. Jaber,
Hani Jneid,
José A. Joglar,
David A. Morrow,
Robert E. O’Connor,
Michael A. Ross,
Leslee J. Shaw

Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals

Moritz Lassé,
Anna P. Pilbrow,
Torsten Kleffmann,
Elin Andersson Överström,
Anne von Zychlinski,
Christopher M. A. Frampton,
Katrina K. Poppe,
Richard W. Troughton,
Lynley K. Lewis,
Timothy C. R. Prickett,
Christopher J. Pemberton,
Arthur M. Richards,
Vicky A. Cameron

Glucose and high-sensitivity troponin T predict a low risk of major adverse cardiac events in emergency department chest pain patients

Pontus Olsson,
Ardavan Khoshnood,
Arash Mokhtari,
Ulf Ekelund

Implementing an early rule-out pathway for acute myocardial infarction in clinical practice

Matthew T H Lowry,
Atul Anand,
Nicholas L Mills

2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Martha Gulati,
Phillip D. Levy,
Debabrata Mukherjee,
Ezra Amsterdam,
Deepak L. Bhatt,
Kim K. Birtcher,
Ron Blankstein,
Jack Boyd,
Renee P. Bullock-Palmer,
Theresa Conejo,
Deborah B. Diercks,
Federico Gentile,
John P. Greenwood,
Erik P. Hess,
Steven M. Hollenberg,
Wael A. Jaber,
Hani Jneid,
José A. Joglar,
David A. Morrow,
Robert E. O’Connor,
Michael A. Ross,
Leslee J. Shaw

2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Martha Gulati,
Phillip D. Levy,
Debabrata Mukherjee,
Ezra Amsterdam,
Deepak L. Bhatt,
Kim K. Birtcher,
Ron Blankstein,
Jack Boyd,
Renee P. Bullock-Palmer,
Theresa Conejo,
Deborah B. Diercks,
Federico Gentile,
John P. Greenwood,
Erik P. Hess,
Steven M. Hollenberg,
Wael A. Jaber,
Hani Jneid,
José A. Joglar,
David A. Morrow,
Robert E. O’Connor,
Michael A. Ross,
Leslee J. Shaw

Analytical and Clinical Considerations in Implementing the Roche Elecsys Troponin T Gen 5 STAT Assay

Leslie J Donato,
Amy M Wockenfus,
Brooke M Katzman,
Nikola A Baumann,
Allan S Jaffe,
Brad S Karon

2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: Executive Summary

Martha Gulati,
Phillip D. Levy,
Debabrata Mukherjee,
Ezra Amsterdam,
Deepak L. Bhatt,
Kim K. Birtcher,
Ron Blankstein,
Jack Boyd,
Renee P. Bullock-Palmer,
Theresa Conejo,
Deborah B. Diercks,
Federico Gentile,
John P. Greenwood,
Erik P. Hess,
Steven M. Hollenberg,
Wael A. Jaber,
Hani Jneid,
José A. Joglar,
David A. Morrow,
Robert E. O’Connor,
Michael A. Ross,
Leslee J. Shaw

2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain

Martha Gulati,
Phillip D. Levy,
Debabrata Mukherjee,
Ezra Amsterdam,
Deepak L. Bhatt,
Kim K. Birtcher,
Ron Blankstein,
Jack Boyd,
Renee P. Bullock-Palmer,
Theresa Conejo,
Deborah B. Diercks,
Federico Gentile,
John P. Greenwood,
Erik P. Hess,
Steven M. Hollenberg,
Wael A. Jaber,
Hani Jneid,
José A. Joglar,
David A. Morrow,
Robert E. O’Connor,
Michael A. Ross,
Leslee J. Shaw

Do cardiac risk scores only muddy the waters?

Edward Carlton

Implementation of an early rule-out pathway for myocardial infarction using a high-sensitivity cardiac troponin T assay

Dennis Sandeman,
Maaz B J Syed,
Dorien M Kimenai,
Kuan Ken Lee,
Atul Anand,
Shruti S Joshi,
Lorraine Dinnel,
Philip R Wenham,
Ken Campbell,
Mary Jarvie,
Donna Galloway,
Mhairi Anderson,
Bappa Roy,
Jack P M Andrews,
Fiona E Strachan,
Amy V Ferry,
Andrew R Chapman,
Sarah Elsby,
Mark Francis,
Robert Cargill,
Anoop S V Shah,
Nicholas L Mills

Cardiotrophin-1 in Patients with Acute Coronary Syndromes: Does it Have a Role?

Humberto Villacorta

Single troponin measurement to rule-out acute myocardial infarction in early presenters

Camilla Fuchs Andersen,
Camilla Bang,
Kasper Glerup Lauridsen,
Christian Alcaraz Frederiksen,
Morten Schmidt,
Tage Jensen,
Nete Hornung,
Bo Løfgren

Early computed tomography coronary angiography in patients with suspected acute coronary syndrome: randomised controlled trial

Alasdair J Gray,
Carl Roobottom,
Jason E Smith,
Steve Goodacre,
Katherine Oatey,
Rachel O’Brien,
Robert F Storey,
Nick Curzen,
Liza Keating,
Attila Kardos,
Dirk Felmeden,
Robert J Lee,
Praveen Thokala,
Steff C Lewis,
David E Newby

Critical appraisal of the 2020 ESC guideline recommendations on diagnosis and risk assessment in patients with suspected non-ST-segment elevation acute coronary syndrome

Evangelos Giannitsis,
Stefan Blankenberg,
Robert H. Christenson,
Norbert Frey,
Stephan von Haehling,
Christian W. Hamm,
Kenji Inoue,
Hugo A. Katus,
Chien-Chang Lee,
James McCord,
Martin Möckel,
Jack Tan Wei Chieh,
Marco Tubaro,
Kai C. Wollert,
Kurt Huber

Validation of the Novel European Society of Cardiology 0/2-hour Algorithm Using Hs-cTnT in the Early Diagnosis of Myocardial Infarction

Karin Wildi,
Pedro Lopez-Ayala,
Luca Koechlin,
Jasper Boeddinghaus,
Thomas Nestelberger,
Desiree Wussler,
Michael Carigiet,
Maria Rubini Giménez,
Òscar Miró,
F. Javier M. Sanchez,
Ivo Strebel,
Danielle M. Gualandro,
Raphael Twerenbold,
Christian Mueller

(Cardiac troponins: current data on the diagnostic value and analytical characteristics of new determination methods)

Aleksey M. Chaulin,
Dmitry V. Duplyakov

Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes

Debkalpa Goswami,
Daniel A. Domingo‐Lopez,
Niamh A. Ward,
Jeffrey R. Millman,
Garry P. Duffy,
Eimear B. Dolan,
Ellen T. Roche

Diagnostic Performance of Serial High-Sensitivity Cardiac Troponin Measurements in the Emergency Setting

Peter A. Kavsak,
Mark K. Hewitt,
Shawn E. Mondoux,
Joshua O. Cerasuolo,
Jinhui Ma,
Natasha Clayton,
Matthew McQueen,
Lauren E. Griffith,
Richard Perez,
Hsien Seow,
Craig Ainsworth,
Dennis T. Ko,
Andrew Worster

Impact of high-sensitivity cardiac troponin implementation on emergency department length of stay, testing, admissions, and diagnoses

James S. Ford,
Ernestine Chaco,
Daniel J. Tancredi,
Bryn E. Mumma

High-Sensitivity Cardiac Troponin on Presentation to Rule Out Myocardial Infarction: A Stepped-Wedge Cluster Randomized Controlled Trial

Atul Anand,
Kuan Ken Lee,
Andrew R. Chapman,
Amy V. Ferry,
Phil D. Adamson,
Fiona E. Strachan,
Colin Berry,
Iain Findlay,
Anne Cruikshank,
Alan Reid,
Paul O. Collinson,
Fred S. Apple,
David A. McAllister,
Donogh Maguire,
Keith A.A. Fox,
David E. Newby,
Chris Tuck,
Ronald Harkess,
Catriona Keerie,
Christopher J. Weir,
Richard A. Parker,
Alasdair Gray,
Anoop S.V. Shah,
Nicholas L. Mills,
Bill Alexander,
Shannon Amoils,
Roma Armstrong,
Anda Bularga,
Bernard L. Croal,
Dimitrios Doudesis,
Colin M. Fischbacher,
Ian Ford,
Takeshi Fujisawa,
Ronnie Harkess,
Dorien M. Kimenai,
Stephen J. Leslie,
Pamela Linksted,
Matthew T.H. Lowry,
Claire MacDonald,
Lucy Marshall,
Filip Mendusic,
John Norrie,
Imran Sadat,
Catherine L. Stables,
Jennifer Stevens,
Stacey D. Stewart,
Laura Stirling,
Caelan Taggart,
Ryan Wereski,
Stephen Young

Guía ESC 2020 sobre el diagnóstico y tratamiento del síndrome coronario agudo sin elevación del segmento ST

Jean-Philippe Collet,
Holger Thiele,
Emanuele Barbato,
Olivier Barthélémy,
Johann Bauersachs,
Deepak L. Bhatt,
Paul Dendale,
Maria Dorobantu,
Thor Edvardsen,
Thierry Folliguet,
Chris P. Gale,
Martine Gilard,
Alexander Jobs,
Peter Jüni,
Ekaterini Lambrinou,
Basil S. Lewis,
Julinda Mehilli,
Emanuele Meliga,
Béla Merkely,
Christian Mueller,
Marco Roffi,
Frans H. Rutten,
Dirk Sibbing,
George C.M. Siontis

2020 Clinical practice guidelines for Acute coronary syndrome without ST segment elevation

O. L. Barbarash,
D. V. Duplyakov,
D. A. Zateischikov,
E. P. Panchenko,
R. M. Shakhnovich,
I. S. Yavelov,
A. N. Yakovlev,
S. A. Abugov,
B. G. Alekyan,
M. V. Arkhipov,
E. Yu. Vasilieva,
A. S. Galyavich,
V. I. Ganyukov,
S. R. Gilyarevskyi,
E. P. Golubev,
E. Z. Golukhova,
N. A. Gratsiansky,
Yu. A. Karpov,
E. D. Kosmacheva,
Yu. M. Lopatin,
V. A. Markov,
N. N. Nikulina,
D. V. Pevzner,
N. V. Pogosova,
A. V. Protopopov,
D. V. Skrypnik,
S. N. Tereshchenko,
S. A. Ustyugov,
A. V. Khripun,
S. V. Shalaev,
V. A. Shpektor,
S. S. Yakushin

The Best of Both Worlds: Eliminating Creatine Kinase-Muscle/Brain (CK-MB) Testing in the Emergency Department Leads to Lower Costs Without Missed Clinical Diagnoses

Prajna A Sahadeo,
Akiva A Dym,
Luke B Berry,
Pegah Bahar,
Arnav Singla,
Melissa Cheta,
Rohan Bhansali,
Sean LaVine,
Jordan Laser,
Mark Richman

Performance of the European Society of Cardiology 0/1-hour algorithm in the diagnosis of myocardial infarction with high-sensitivity cardiac troponin: Systematic review and meta-analysis

Lucrecia M Burgos,
Marcelo Trivi,
Juan P Costabel

External validation of the clinical chemistry score

Karin Wildi,
Jasper Boeddinghaus,
Thomas Nestelberger,
Philip Haaf,
Luca Koechlin,
Pedro Ayala Lopez,
Joan Walter,
Patrick Badertscher,
Paul David Ratmann,
Òscar Miró,
F. Javier Martin-Sanchez,
Piotr Muzyk,
Marina Kaeslin,
Maria RubiniGiménez,
Danielle M. Gualandro,
Franz Buergler,
Dagmar I. Keller,
Michael Christ,
Raphael Twerenbold,
Christian Mueller

Single high-sensitivity troponin levels to assess patients with potential acute coronary syndromes

Cara Barnes,
Daniel M Fatovich,
Stephen P J Macdonald,
Richard F Alcock,
Jon R Spiro,
Tom G Briffa,
Carl J Schultz,
Graham S Hillis

Diagnostic Performance of High-Sensitivity Cardiac Troponin T Strategies and Clinical Variables in a Multisite US Cohort

Brandon R. Allen,
Robert H. Christenson,
Scott A. Cohen,
Richard Nowak,
R. Gentry Wilkerson,
Bryn Mumma,
Troy Madsen,
James McCord,
Maite Huis in’t Veld,
Michael Massoomi,
Jason P. Stopyra,
Cindy Montero,
Michael T. Weaver,
Kai Yang,
Simon A. Mahler

2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Jean-Philippe Collet,
Holger Thiele,
Emanuele Barbato,
Olivier Barthélémy,
Johann Bauersachs,
Deepak L Bhatt,
Paul Dendale,
Maria Dorobantu,
Thor Edvardsen,
Thierry Folliguet,
Chris P Gale,
Martine Gilard,
Alexander Jobs,
Peter Jüni,
Ekaterini Lambrinou,
Basil S Lewis,
Julinda Mehilli,
Emanuele Meliga,
Béla Merkely,
Christian Mueller,
Marco Roffi,
Frans H Rutten,
Dirk Sibbing,
George C M Siontis,
Adnan Kastrati,
Mamas A Mamas,
Victor Aboyans,
Dominick J Angiolillo,
Hector Bueno,
Raffaele Bugiardini,
Robert A Byrne,
Silvia Castelletti,
Alaide Chieffo,
Veronique Cornelissen,
Filippo Crea,
Victoria Delgado,
Heinz Drexel,
Marek Gierlotka,
Sigrun Halvorsen,
Kristina Hermann Haugaa,
Ewa A Jankowska,
Hugo A Katus,
Tim Kinnaird,
Jolanda Kluin,
Vijay Kunadian,
Ulf Landmesser,
Christophe Leclercq,
Maddalena Lettino,
Leena Meinila,
Darren Mylotte,
Gjin Ndrepepa,
Elmir Omerovic,
Roberto F E Pedretti,
Steffen E Petersen,
Anna Sonia Petronio,
Gianluca Pontone,
Bogdan A Popescu,
Tatjana Potpara,
Kausik K Ray,
Flavio Luciano,
Dimitrios J Richter,
Evgeny Shlyakhto,
Iain A Simpson,
Miguel Sousa-Uva,
Robert F Storey,
Rhian M Touyz,
Marco Valgimigli,
Pascal Vranckx,
Robert W Yeh,
Emanuele Barbato,
Olivier Barthélémy,
Johann Bauersachs,
Deepak L Bhatt,
Paul Dendale,
Maria Dorobantu,
Thor Edvardsen,
Thierry Folliguet,
Chris P Gale,
Martine Gilard,
Alexander Jobs,
Peter Jüni,
Ekaterini Lambrinou,
Basil S Lewis,
Julinda Mehilli,
Emanuele Meliga,
Béla Merkely,
Christian Mueller,
Marco Roffi,
Frans H Rutten,
Dirk Sibbing,
George C M Siontis

Clinical History and Detectable Troponin Concentrations below the 99th Percentile for Risk Stratification of Patients with Chest Pain and First Normal Troponin

Agustín Fernández-Cisnal,
Ernesto Valero,
Sergio García-Blas,
Vicente Pernias,
Adela Pozo,
Arturo Carratalá,
Jessika González,
José Noceda,
Gema Miñana,
Julio Núñez,
Juan Sanchis

High-sensitivity cardiac troponins: detection and central analytical characteristics

A. M. Chaulin,
O. E. Abashina,
D. V. Duplyakov

Acute Myocardial Infarction Biosensor: A Review From Bottom Up

J.A. Reyes-Retana,
L.C. Duque-Ossa

Discordance of High-Sensitivity Troponin Assays in Patients With Suspected Acute Coronary Syndromes

Júlia Karády,
Thomas Mayrhofer,
Maros Ferencik,
John T. Nagurney,
James E. Udelson,
Andreas A. Kammerlander,
Jerome L. Fleg,
W. Frank Peacock,
James L. Januzzi,
Wolfgang Koenig,
Udo Hoffmann

Baseline High Sensitivity Cardiac Troponin I Level Below Limit of Quantitation Rules Out Acute Myocardial Infarction in the Emergency Department

Bernard Cook,
James McCord,
Michael Hudson,
Waleed Al-Darzi,
Michele Moyer,
Gordon Jacobsen,
Richard Nowak

Single vs Serial Measurements of Cardiac Troponin Level in the Evaluation of Patients in the Emergency Department With Suspected Acute Myocardial Infarction

Maereg Wassie,
Ming-Sum Lee,
Benjamin C. Sun,
Yi-Lin Wu,
Aileen S. Baecker,
Rita F. Redberg,
Maros Ferencik,
Ernest Shen,
Visanee Musigdilok,
Adam L. Sharp

Troponin Testing in the Emergency Department—When 2 Become 1

Barbra Eva Backus,
Richard Body,
Michael Barnett Weinstock

Comparison of a single high-sensitivity cardiac troponin T measurement with the HEART score for rapid rule-out of acute myocardial infarction in a primary care emergency setting: a cohort study

Tonje R Johannessen,
Dan Atar,
Odd Martin Vallersnes,
Anne Cecilie K Larstorp,
Ibrahimu Mdala,
Sigrun Halvorsen

Next-Day Troponin Tests in Real-World Implementation of Baseline Troponin Rule-Out of Myocardial Infarction Demonstrates Minimal Delayed Troponin Rises

Joanna M. Young,
Jodie N. Sage,
John W. Pickering,
Laura Bannister,
Sally Aldous,
Peter M. George,
Martin P. Than

Antibody Epitope and Affinity Determination of the Myocardial Infarction Marker Myoglobin by SPR-Biosensor Mass Spectrometry

Delia Mihoc,
Loredana-Mirela Lupu,
Pascal Wiegand,
Wolfgang Kleinekofort,
Oliver Müller,
Friedemann Völklein,
Michael O. Glocker,
Frederik Barka,
Günes Barka,
Michael Przybylski

High-sensitivity methods for cardiac troponins: The mission is not over yet

A Practical Approach for the Use of High-Sensitivity Cardiac Troponin Assays in the Evaluation of Patients With Chest Pain

Rabih R. Azar,
Antoine Sarkis,
Evangelos Giannitsis

A fluorescence sandwich immunoassay for the real-time continuous detection of glucose and insulin in live animals

Mahla Poudineh,
Caitlin L. Maikawa,
Eric Yue Ma,
Jing Pan,
Dan Mamerow,
Yan Hang,
Sam W. Baker,
Ahmad Beirami,
Alex Yoshikawa,
Michael Eisenstein,
Seung Kim,
Jelena Vučković,
Eric A. Appel,
H. Tom Soh

Cardiac Troponins: Contemporary Biological Data and New Methods of Determination

Aleksey Chaulin

Gli algoritmi rapidi per NSTEMI tra necessità cliniche e criticità diagnostiche

Marco MORETTI,
Alessio GAMBONI,
Piero CAPPELLETTI,
Maria A. BURGIO,
Massimiliano MANNO,
Elisabetta STENNER,
Francesca VENEZIANI,
Lucia MALLOGGI,
Margherita MORANDINI,
Giulio MARINO,
Martina DI PIETRO,
Deborah MAZZEI,
Jessica VIOLA,
Dina DI MARIA,
Daniela RUBIN,
Matteo CASSIN,
Gianni A. GALLI

Aggiornamenti sui metodi di determinazione e potenzialità diagnostiche delle troponine cardiache

Aleksey M. CHAULIN

2020 Clinical practice guidelines for Acute ST-segment elevation myocardial infarction

(RSC) Russian Society of Cardiology

Practice pattern of use of high sensitivity troponin in the outpatient settings

Enrico G. Ferro,
Ankeet S. Bhatt,
Guohai Zhou,
Karen Fiumara,
Jason H. Wasfy,
Thomas D. Sequist,
David A. Morrow,
Benjamin M. Scirica

Short-term prognosis of unstable angina in the era of high-sensitivity cardiac troponin: insights for early rule-out strategies

Guglielmo Gallone,
Marco Magnoni,
Vittoria Vergani,
Ferruccio Ceriotti,
Giulia Angeloni,
Paola Scarano,
Attilio Maseri,
Domenico Cianflone

Copeptin combined with either non-high sensitivity or high sensitivity cardiac troponin for instant rule-out of suspected non-ST segment elevation myocardial infarction

Evangelos Giannitsis,
Anna Slagman,
Christian W. Hamm,
Stefan Gehrig,
Joern O. Vollert,
Kurt Huber

Diagnostic Reclassification by a High-Sensitivity Cardiac Troponin Assay

Bryn E. Mumma,
Scott D. Casey,
Robert K. Dang,
Michelle K. Polen,
Jasmanpreet C. Kaur,
John Rodrigo,
Daniel J. Tancredi,
Robert A. Narverud,
Ezra A. Amsterdam,
Nam Tran

MGUS Predicts Worse Prognosis in Patients with Coronary Artery Disease

Zhao Xu,
Yifeng Sun,
Tianhong Xu,
Yidan Shi,
Lifan Liang,
Peng Liu,
Junbo Ge

Limit of detection of troponin discharge strategy versus usual care: randomised controlled trial

Edward Watts Carlton,
Jenny Ingram,
Hazel Taylor,
Joel Glynn,
Rebecca Kandiyali,
Sarah Campbell,
Lucy Beasant,
Shahid Aziz,
Peter Beresford,
Jason Kendall,
Adam Reuben,
Jason E Smith,
Rebecca Chapman,
Siobhan Creanor,
Jonathan Richard Benger

Using the clinical chemistry score in the emergency department to detect adverse cardiac events: a diagnostic accuracy study

Peter A. Kavsak,
Joshua O. Cerasuolo,
Dennis T. Ko,
Jinhui Ma,
Jonathan Sherbino,
Shawn E. Mondoux,
Natasha Clayton,
Stephen A. Hill,
Matthew McQueen,
Lauren E. Griffith,
Shamir R. Mehta,
Richard Perez,
Hsien Seow,
P.J. Devereaux,
Andrew Worster

High-sensitivity cardiac troponin on presentation to rule out myocardial infarction: a stepped-wedge cluster randomised controlled trial

Atul Anand,
Kuan Ken Lee,
Andrew R. Chapman,
Amy V. Ferry,
Phil D. Adamson,
Fiona E. Strachan,
Colin Berry,
Iain Findlay,
Anne Cruikshank,
Alan Reid,
Paul O. Collinson,
Fred S. Apple,
David A. McAllister,
Donogh Maguire,
Keith A.A. Fox,
David E. Newby,
Chris Tuck,
Ronald Harkess,
Catriona Keerie,
Christopher J. Weir,
Richard A. Parker,
Alasdair Gray,
Anoop S.V. Shah,
Nicholas L. Mills

Prospective comparative evaluation of the European Society of Cardiology (ESC) 1-hour and a 2-hour rapid diagnostic algorithm for myocardial infarction using high-sensitivity troponin-T

James E. Andruchow,
Timothy Boyne,
Isolde Seiden-Long,
Dongmei Wang,
Shabnam Vatanpour,
Grant Innes,
Andrew D. McRae

Lot-to-Lot Variation for Commercial High-Sensitivity Cardiac Troponin: Can We Realistically Report Down to the Assay’s Limit of Detection?

Alan H B Wu,
Peter A Kavsak,
Kristin Moberg Aakre,
Robert H Christenson,
Dina N Greene,
Fred S Apple,
W Frank Peacock,
Judd E Hollander,
James A de Lemos,
David Morrow,
James Januzzi,
Allan S Jaffe

Undetectable high-sensitivity troponin in combination with clinical assessment for risk stratification of patients with chest pain and normal troponin at hospital arrival

Juan Sanchis,
Ernesto Valero,
Sergio García Blas,
Esther Barba,
Vicente Pernias,
Gema Miñana,
José Brasó,
Agustín Fernandez-Cisnal,
Jessika Gonzalez,
José Noceda,
Arturo Carratalá,
Francisco J Chorro,
Julio Núñez,
John W Pickering

Risk Stratification for Patients with Chest Pain Discharged Home from the Emergency Department

Peter A. Kavsak,
Joshua O. Cerasuolo,
Shawn E. Mondoux,
Jonathan Sherbino,
Jinhui Ma,
Brock K. Hoard,
Richard Perez,
Hsien Seow,
Dennis T. Ko,
Andrew Worster

High-sensitivity-cardiac troponin for accelerated diagnosis of acute myocardial infarction: A systematic review and meta-analysis

Chien-Chang Lee,
Sih-Shiang Huang,
Yee Hui Yeo,
Yi-Ting Hou,
James Yeongjun Park,
Kenji Inoue,
Wan-Ting Hsu

CSANZ Position Statement on the Evaluation of Patients Presenting With Suspected Acute Coronary Syndromes During the COVID-19 Pandemic

William A. Parsonage,
Louise Cullen,
David Brieger,
Graham S. Hillis,
Arthur Nasis,
Nathan Dwyer,
Sudhir Wahi,
Sidney Lo,
Martin Than,
Andrew Kerr,
Gerard Devlin,
Derek K. Chew

Atherosclerotic Cardiovascular Disease Risk Stratification Based on Measurements of Troponin and Coronary Artery Calcium

Yader Sandoval,
Suzette J. Bielinski,
Lori B. Daniels,
Michael J. Blaha,
Erin D. Michos,
Andrew P. DeFilippis,
Moyses Szklo,
Christopher deFilippi,
Nicholas B. Larson,
Paul A. Decker,
Allan S. Jaffe

Admission troponin measurement for the diagnosis of myocardial infarction: the search for one and done continues

Paul Collinson

Safety and efficacy of the European Society of Cardiology 0/1-hour algorithm for diagnosis of myocardial infarction: systematic review and meta-analysis

Cho-Han Chiang,
Cho-Hung Chiang,
Gin Hoong Lee,
Weng-Tein Gi,
Yuan-Kun Wu,
Sih-Shiang Huang,
Yee Hui Yeo,
Evangelos Giannitsis,
Chien-Chang Lee

Accuracy or efficiency? Striking the balance for your chest pain pathway

Richard Body

Comparison of 0/3-Hour Rapid Rule-Out Strategies Using High-Sensitivity Cardiac Troponin I in a US Emergency Department

Yader Sandoval,
Stephen W. Smith,
Karen Schulz,
Anne Sexter,
Fred S. Apple

High sensitivity measurement of cardiac troponins: algorithms, interpretations, clinical consequences

V. V. Velkov

Early kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction

John W. Pickering,
Joanna M. Young,
Peter M. George,
Christopher J. Pemberton,
Antony Watson,
Sally J. Aldous,
Toby Verryt,
Richard W. Troughton,
A. Mark Richards,
Fred S. Apple,
Martin P. Than

Value of Repeated Troponin Measurements to Improve the Safety of the HEART Score for Chest Pain Patients at the Emergency Department

Marten Ras,
Johannes B. Reitsma,
Arno W. Hoes,
A. Jacob Six,
Judith M. Poldervaart

Detection of Acute Coronary Syndrome using Electrocardiogram Signal Analysis

Muhammad Umar Khan,
Sumair Aziz,
Javeria Mumtaz Ch.,
Anber Shahjehan,
Atif Imtiaz,
Athar Waseem

Diagnostic accuracy of troponin T measured ≥6h after symptom onset for ruling out myocardial infarction

Ardavan Khoshnood,
Marie Erlandsson,
Nazim Isma,
Troels Yndigegn,
Arash Mokhtari

Intraoperative Troponin Elevation in Liver Transplantation Is Independently Associated With Mortality: A Prospective Observational Study

Almudena L. Vilchez‐Monge,
Ignacio Garutti,
Concepción Jimeno,
Matilde Zaballos,
Consuelo Jimenez,
Luis Olmedilla,
Patricia Piñeiro,
Patricia Duque,
Magdalena Salcedo,
Jose M. Asencio,
Jose A Lopez‐Baena,
Przemyslaw Maruszewski,
Rafael Bañares,
Jose M. Perez‐Peña

Cardiac biomarkers by point-of-care testing – back to the future?

Paul Collinson

Effect of miR-26a-5p targeting ADAM17 gene on apoptosis, inflammatory factors and oxidative stress response of myocardial cells in hypoxic model

Xia Wen,
Ying Yin,
Xiaohong Li,
Tao He,
Pengfei Wang,
Mingzhe Song,
Jiangfeng Gao

Single test rule-out of acute myocardial infarction using the limit of detection of a new high-sensitivity troponin I assay

Richard Body,
Niall Morris,
Paul Collinson

Clinical outcomes for chest pain patients discharged home from emergency departments using high-sensitivity versus conventional cardiac troponin assays

Geoffrey Lau,
Maria Koh,
Peter A. Kavsak,
Michael J. Schull,
David W.J. Armstrong,
Jacob A. Udell,
Peter C. Austin,
Xuesong Wang,
Dennis T. Ko

Risk Stratification Using High-Sensitivity Cardiac Troponin T in Patients With Suspected Acute Coronary Syndrome

Andrew R. Chapman,
Dennis Sandeman,
Amy V. Ferry,
Stacey Stewart,
Fiona E. Strachan,
Ryan Wereski,
Anda Bularga,
Atul Anand,
Anoop S.V. Shah,
Nicholas L. Mills

Serial high-sensitivity cardiac troponin T measurements to rule out acute myocardial infarction and a single high baseline measurement for swift rule-in: A systematic review and meta-analysis

M Arslan,
A Dedic,
E Boersma,
EA Dubois

RAPID-CPU: a prospective study on implementation of the ESC 0/1-hour algorithm and safety of discharge after rule-out of myocardial infarction

Kiril M Stoyanov,
Hauke Hund,
Moritz Biener,
Jochen Gandowitz,
Christoph Riedle,
Julia Löhr,
Matthias Mueller-Hennessen,
Mehrshad Vafaie,
Hugo A Katus,
Evangelos Giannitsis

The impact of an acute chest pain pathway on the investigation and management of cardiac chest pain

Mark Sweeney,
Gillian Bleeze,
Sarah Storey,
Alexander Cairns,
Alexander Taylor,
Catherine Holmes,
Steve Hart,
Nick Lawrance,
William G Oldfield,
Christopher S Baker

The Asia-Pacific Society of Cardiology (APSC) Expert Committee Consensus Recommendations for Assessment of Suspected Acute Coronary Syndrome Using High-Sensitivity Cardiac Troponin T in the Emergency Department

Wei Chieh Jack Tan,
Kenji Inoue,
Laila AbdelWareth,
Evangelos Giannitsis,
Sazzli Kasim,
Masayuki Shiozaki,
Tar Choon Aw,
Federick Cheng,
Ho Thuong Dung,
Yi-Heng Li,
Swee Han Lim,
Antonia Anna Lukito,
Martin Than,
Fang-Yeh Chu,
Tom Devasia,
Chien-Chang Lee,
Arintaya Phrommintikul,
Jong-Chan Youn,
Derek P. Chew

Continuous detection of glucose and insulin in live animals

Mahla Poudineh,
Caitlin L. Maikawa,
Eric Yue Ma,
Jing Pan,
Dan Mamerow,
Yan Hang,
Sam W. Baker,
Ahmad Beirami,
Michael Eisenstein,
Seung Kim,
Jelena Vučković,
Eric A. Appel,
H. Tom Soh

Biomarkers for coronary artery disease and heart failure

Peter A. Kavsak,
Alan H.B. Wu

CJEM Debate Series: #TropandGo – Negative high sensitivity troponin testing is safe as a final test for most emergency department patients with chest pain

Andrew D. McRae,
James E. Andruchow,
Frank X. Scheuermeyer,
Jim Christenson,
Paul Atkinson

Comparison of four decision aids for the early diagnosis of acute coronary syndromes in the emergency department

Richard Body,
Niall Morris,
Charles Reynard,
Paul O Collinson

Raccomandazioni del GdS MM SIPMeL per l'uso dei biomarcatori cardiaci in NSTEMI. Parte seconda: evidenze nella diagnosi

Lucia Malloggi,
Piero Cappelletti,
Marco Moretti,
Francesca Veneziani,
Massimiliano Manno,
Maria A. Burgio,
Alessio Gamboni,
Matteo Cassin,
Elisabetta Stenner,
Margherita Morandini,
Giulio Marino,
Martina Di Pietro,
Deborah Mazzei,
Jessica Viola,
Dina Di Maria,
Daniela Rubin,
Gianni A. Galli

Raccomandazioni del GdS MM SIPMeL per l'uso dei marcatori miocardiaci nella diagnostica di NSTEMI. Parte terza: prognosi e stratificazione del rischio

Lucia Malloggi,
Piero Cappelletti,
Maria A. Burgio,
Martina Di Pietro,
Marco Moretti,
Francesca Veneziani,
Massimiliano Manno,
Elisabetta Stenner,
Alessio Gamboni,
Matteo Cassin,
Margherita Morandini,
Giulio Marino,
Deborah Mazzei,
Jessica Viola,
Dina Di Maria,
Daniela Rubin,
Gianni A. Galli

Spotlight on N-STEMI ACS: getting the right patients the right treatment, and at the right time

Thomas A. Kite,
Bernard J. Gersh,
Anthony H. Gershlick

High-Sensitivity Troponin and the Application of Risk Stratification Thresholds in Patients With Suspected Acute Coronary Syndrome

Anda Bularga,
Kuan Ken Lee,
Stacey Stewart,
Amy V. Ferry,
Andrew R. Chapman,
Lucy Marshall,
Fiona E. Strachan,
Anne Cruickshank,
Donogh Maguire,
Colin Berry,
Iain Findlay,
Anoop S.V. Shah,
David E. Newby,
Nicholas L. Mills,
Atul Anand

Low High-Sensitivity Troponin Thresholds Identify Low-Risk Patients With Chest Pain Unlikely to Benefit From Further Risk Stratification

James E. Andruchow,
Timothy Boyne,
Grant Innes,
Shabnam Vatanpour,
Isolde Seiden-Long,
Dongmei Wang,
Eddy Lang,
Andrew D. McRae

Clinical utility of magnetocardiography in cardiology for the detection of myocardial ischemia

A. John Camm,
Robert Henderson,
Donatella Brisinda,
Richard Body,
Richard G. Charles,
Ben Varcoe,
Riccardo Fenici

Using High Sensitivity Troponins to Rule Out Acute Coronary Syndrome and Lower Admission Rates

Whitney Potomac,
Deborah B. Diercks

A paper microfluidics-based fluorescent lateral flow immunoassay for point-of-care diagnostics of non-communicable diseases

Satheesh Natarajan,
Fengmei Su,
Joseph Jayaraj,
Malay I. Iesh Shah,
Youju Huang

Enhanced triage for patients with suspected cardiac chest pain: the History and Electrocardiogram-only Manchester Acute Coronary Syndromes decision aid

Abdulrhman Alghamdi,
Laura Howard,
Charles Reynard,
Philip Moss,
Heather Jarman,
Kevin Mackway-Jones,
Simon Carley,
Richard Body

Machine Learning to Predict the Likelihood of Acute Myocardial Infarction

Martin P. Than,
John W. Pickering,
Yader Sandoval,
Anoop S.V. Shah,
Athanasios Tsanas,
Fred S. Apple,
Stefan Blankenberg,
Louise Cullen,
Christian Mueller,
Johannes T. Neumann,
Raphael Twerenbold,
Dirk Westermann,
Agim Beshiri,
Nicholas L. Mills,
Peter M George,
A Mark Richards,
Richard W Troughton,
Sally J Aldous,
Andrew R Chapman,
Atul Anand,
Jaimi Greenslade,
William Parsonage,
Jasper Boeddinghaus,
Karin Wildi,
Thomas Nestelberger,
Patrick Badertscher,
Shaoqing Du,
Janel Huang,
Stephen W Smith,
Nils A Sörensen,
Francisco Ojeda

Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain-the WESTCOR study: study design

Hilde L. Tjora,
Ole-Thomas Steiro,
Jørund Langørgen,
Rune Bjørneklett,
Ottar K. Nygård,
Renate Renstrøm,
Øyvind Skadberg,
Vernon V. S. Bonarjee,
Bertil Lindahl,
Paul Collinson,
Torbjørn Omland,
Kjell Vikenes,
Kristin M. Aakre

A Multicenter Assessment of the Sensitivity and Specificity for a Single High-Sensitivity Cardiac Troponin Test at Emergency Department Presentation for Hospital Admission

Peter A Kavsak,
Andrew McRae,
Shabnam Vatanpour,
Ola Z Ismail,
Andrew Worster

Rapid rule out of acute myocardial infarction in the observe zone using a combination of presentation N-terminal pro-B-type natriuretic peptide and high-sensitivity cardiac troponin I

Yao Wang,
Lihua Dai,
Ning Wang,
Yingying Zhu,
Miao Chen,
Hairong Wang

High-sensitivity troponin T and long-term adverse cardiac events among patients presenting with suspected acute coronary syndrome in Singapore

Z Lin,
SH Lim,
SJT Chua,
ES, Tai,
YH Chan,
AM Richards

Diagnostic Accuracy of a High-Sensitivity Cardiac Troponin Assay with a Single Serum Test in the Emergency Department

Richard Body,
Raphael Twerenbold,
Catrin Austin,
Jasper Boeddinghaus,
Malak Almashali,
Thomas Nestelberger,
Niall Morris,
Patrick Badertscher,
Garry McDowell,
Karin Wildi,
Phil Moss,
Maria Rubini Gimenez,
Heather Jarman,
Nina Bigler,
Rachael Einemann,
Luca Koechlin,
Ghazaleh Pourmahram,
John Todd,
Christian Mueller,
Anthony Freemont

Myocardial Infarction Risk Stratification With a Single Measurement of High-Sensitivity Troponin I

Yader Sandoval,
Richard Nowak,
Christopher R. deFilippi,
Robert H. Christenson,
W. Frank Peacock,
James McCord,
Alexander T. Limkakeng,
Anne Sexter,
Fred S. Apple

Multicentre cross-sectional observational registry to monitor the safety of early discharge after rule-out of acute myocardial infarction by copeptin and troponin: the Pro-Core registry

Evangelos Giannitsis,
Piers Clifford,
Anna Slagman,
Ralph Ruedelstein,
Christoph Liebetrau,
Christian Hamm,
Didier Honnart,
Kurt Huber,
Jörn Ole Vollert,
Carlo Simonelli,
Malte Schröder,
Jan C Wiemer,
Matthias Mueller-Hennessen,
Hinrich Schroer,
Kim Kastner,
Martin Möckel

Application of High-Sensitivity Troponin in Suspected Myocardial Infarction

Johannes T. Neumann,
Raphael Twerenbold,
Francisco Ojeda,
Nils A. Sörensen,
Andrew R. Chapman,
Anoop S.V. Shah,
Atul Anand,
Jasper Boeddinghaus,
Thomas Nestelberger,
Patrick Badertscher,
Arash Mokhtari,
John W. Pickering,
Richard W. Troughton,
Jaimi Greenslade,
William Parsonage,
Matthias Mueller-Hennessen,
Tommaso Gori,
Tomas Jernberg,
Niall Morris,
Christoph Liebetrau,
Christian Hamm,
Hugo A. Katus,
Thomas Münzel,
Ulf Landmesser,
Veikko Salomaa,
Licia Iacoviello,
Marco M. Ferrario,
Simona Giampaoli,
Frank Kee,
Barbara Thorand,
Annette Peters,
Rossana Borchini,
Torben Jørgensen,
Stefan Söderberg,
Susana Sans,
Hugh Tunstall-Pedoe,
Kari Kuulasmaa,
Thomas Renné,
Karl J. Lackner,
Andrew Worster,
Richard Body,
Ulf Ekelund,
Peter A. Kavsak,
Till Keller,
Bertil Lindahl,
Philipp Wild,
Evangelos Giannitsis,
Martin Than,
Louise A. Cullen,
Nicholas L. Mills,
Christian Mueller,
Tanja Zeller,
Dirk Westermann,
Stefan Blankenberg

Sensitivity of undetectable level of high-sensitivity troponin T at presentation in a large non-ST-segment elevation myocardial infarction cohort of early presenters

Lina Ljung,
Camilla Reichard,
Peter Hagerman,
Kai M. Eggers,
Mats Frick,
Bertil Lindahl,
Rikard Linder,
Arne Martinsson,
Dina Melki,
Per Svensson,
Tomas Jernberg

High-sensitivity Cardiac Troponin for the Evaluation of Patients With Suspected ACS: A True or a False Friend?

Juan Sanchis,
Aitor Alquézar-Arbé,
Jordi Ordóñez-Llanos,
Alfredo Bardají

La troponina cardiaca de alta sensibilidad en la evaluación del paciente con sospecha de SCA: ¿verdadera o falsa amiga?

Juan Sanchis,
Aitor Alquézar-Arbé,
Jordi Ordóñez-Llanos,
Alfredo Bardají

Is high-sensitivity troponin, alone or in combination with copeptin, sensitive enough for ruling out NSTEMI in very early presenters at admission? A post hoc analysis performed in emergency departments

Camille Chenevier-Gobeaux,
Mustapha Sebbane,
Christophe Meune,
Sophie Lefebvre,
Anne-Marie Dupuy,
Guillaume Lefèvre,
Nicolas Peschanski,
Patrick Ray

High-sensitivity cardiac troponins: sex-specific values in clinical practice. Precision or confusion?

Hugo R. Ramos,
Luis E. López,
Walter Quiroga Castro,
César MJ. Serra

Diagnostic accuracy of the T-MACS decision aid with a contemporary point-of-care troponin assay

Richard Body,
Malak Almashali,
Niall Morris,
Phil Moss,
Heather Jarman,
Andrew Appelboam,
Richard Parris,
Louisa Chan,
Alison Walker,
Mark Harrison,
Andrea Wootten,
Garry McDowell

Use of Cardiac Troponin Testing in the Outpatient Setting

Steven J. Ross,
Nikhil H. Shah,
Steve A. Noutong Njapo,
Daniel J. Cordiner,
David E. Winchester

High-sensitivity troponin allows accurate rapid diagnosis and discharge but it is not a substitute for a comprehensive patient evaluation

Antonio Martellini,
Carlo di Mario

Clinical use of cardiac troponin for acute cardiac care and emerging opportunities in the outpatient setting

Yader Sandoval,
Korosh Sharain,
Amy K. Saenger,
Stephen W. Smith,
Fred S. Apple,
Allan S. Jaffe

Susceptibility of Cardiac Troponin Assays to Biotin Interference

Ithiel J Frame,
Parag H Joshi,
Caroline Mwangi,
Ian Gunsolus,
James A De Lemos,
Sandeep R Das,
Ravi Sarode,
Jyoti Balani,
Fred S Apple,
Alagarraju Muthukumar

Role of High-sensitivity Cardiac Troponin in Acute Coronary Syndrome

Mahesh Anantha Narayanan,
Santiago Garcia

Recommendations for Institutions Transitioning to High-Sensitivity Troponin Testing

James L. Januzzi,
Simon A. Mahler,
Robert H. Christenson,
Jennifer Rymer,
L. Kristin Newby,
Richard Body,
David A. Morrow,
Allan S. Jaffe

Diagnostic accuracy of contemporary and high-sensitivity cardiac troponin assays used in serial testing, versus single-sample testing as a comparator, to triage patients suspected of acute non-ST-segment elevation myocardial infarction: a systematic review protocol

Zhivko Zhelev,
Hirotaka Ohtake,
Mitsunaga Iwata,
Teruhiko Terasawa,
Morwenna Rogers,
Jaime L Peters,
Chris Hyde

Global Adoption of High-Sensitivity Cardiac Troponins and the Universal Definition of Myocardial Infarction

Atul Anand,
Anoop S V Shah,
Agim Beshiri,
Allan S Jaffe,
Nicholas L Mills

Fourth universal definition of myocardial infarction (2018)

Kristian Thygesen,
Joseph S Alpert,
Allan S Jaffe,
Bernard R Chaitman,
Jeroen J Bax,
David A Morrow,
Harvey D White,
Kristian Thygesen,
Joseph S Alpert,
Allan S Jaffe,
Bernard R Chaitman,
Jeroen J Bax,
David A Morrow,
Harvey D White,
Hans Mickley,
Filippo Crea,
Frans Van de Werf,
Chiara Bucciarelli-Ducci,
Hugo A Katus,
Fausto J Pinto,
Elliott M Antman,
Christian W Hamm,
Raffaele De Caterina,
James L Januzzi,
Fred S Apple,
Maria Angeles Alonso Garcia,
S Richard Underwood,
John M Canty,
Alexander R Lyon,
P J Devereaux,
Jose Luis Zamorano,
Bertil Lindahl,
William S Weintraub,
L Kristin Newby,
Renu Virmani,
Pascal Vranckx,
Don Cutlip,
Raymond J Gibbons,
Sidney C Smith,
Dan Atar,
Russell V Luepker,
Rose Marie Robertson,
Robert O Bonow,
P Gabriel Steg,
Patrick T O’Gara,
Keith A A Fox,
David Hasdai,
Victor Aboyans,
Stephan Achenbach,
Stefan Agewall,
Thomas Alexander,
Alvaro Avezum,
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The Single High-Sensitivity Serum Cardiac Troponin T Level: A Significant Advance for Chest Pain Pathways?

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