Current Issue
- June 9, 2026
- vol. 123
- no. 23
- This paper presents the finding and initial characterization of a positive allosteric modulator (PAM), DC-98-LC74, that is selective for adult muscle acetylcholine receptor (AChR). Our data indicate that DC-98-LC74 increases the resting open ...The muscle nicotinic acetylcholine receptor (AChR) is the key mediator of neuromuscular signal transmission and is essential for all voluntary movement in our body. In this study, we present DC-98-LC74, a positive allosteric modulator (PAM) for the adult ...
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- Richard Feynman described a decision-making problem and its solution in handwritten notes, but the meaning of the notes has been a mystery for almost 50 y. We decipher the problem and solution from Feynman’s notes, and prove that Feynman’s ...In the 1970s, physicist Richard Feynman turned lunch with a friend into a math problem—how to optimize dish selection over multiple meals—but his handwritten notes remained a mystery for decades. Here we present the fully deciphered problem and solution, ...
- While generative AI has been shown to enhance productivity, its influence on learning new skills remains unclear. Our research examines the impact of generative AI, specifically GPT-4, on student learning in math education. Through a large-...Generative AI is poised to revolutionize how humans work, and has already demonstrated promise in significantly improving human productivity. A key question is how generative AI affects learning—namely, how humans acquire new skills as they perform tasks. ...
- We developed a strategy to identify gut bacteria functionally linked to the development of multiple sclerosis (MS). To minimize confounders, we analyzed microbiota composition in a large cohort of monozygotic twins discordant for MS and ...We developed a two-tiered strategy aiming to identify gut bacteria functionally linked to the development of multiple sclerosis (MS). First, we compared gut microbial profiles in a cohort of 81 monozygotic twins discordant for MS. This approach allowed to ...
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