Neural correlates of affective and non-affective cognition in obsessive compulsive disorder: A meta-analysis of functional imaging studies

“…Our finding of rich club regions is to a large extent consistent with previous research on whole-brain structural networks in OCD ( Zhou et al, 2020 ). Additionally, the putamen and precentral gyrus were also found to be important hubs in the present study; these regions were also associated with OCD pathomechanism, including in the cortico-striatal circuits in previous studies ( Jang et al, 2010 , Kubota et al, 2019 , Rasgon et al, 2017 , Zhou et al, 2020 ). Moreover, these rich club nodes overlapped with the default mode network (DMN).…”

“…Such an approach may improve not only patient satisfaction but also long-term psychological well-being. Similar integrative strategies have been suggested for other disorders involving altered attentional bias processing, such as obsessive-compulsive and social anxiety disorders ( 24 , 25 ).…”

“…Nonetheless, the standardized processing protocol we applied across all datasets, the strong task effect we observed, and the robustness of our findings to sensitivity analyses suggest we successfully captured domain-level inhibitory control independent of individual task effects. While several meta-analyses have examined inhibitory control in OCD (4,(8)(9)(10)(11)29), our findings go beyond the previous literature by disentangling inhibitory control from broader executive function tasks, which previous studies conflated. Further, our results add to emerging evidence for distinct patterns of lifespan neurodevelopment and aging on neural recruitment during cognitive inhibition and response inhibition (38), underscoring the need to consider developmental stage and task demands when interpreting inhibitory control deficits in OCD.…”

“…Our finding of rich club regions is to a large extent consistent with previous research on whole-brain structural networks in OCD ( Zhou et al, 2020 ). Additionally, the putamen and precentral gyrus were also found to be important hubs in the present study; these regions were also associated with OCD pathomechanism, including in the cortico-striatal circuits in previous studies ( Jang et al, 2010 , Kubota et al, 2019 , Rasgon et al, 2017 , Zhou et al, 2020 ). Moreover, these rich club nodes overlapped with the default mode network (DMN).…”

“…Such an approach may improve not only patient satisfaction but also long-term psychological well-being. Similar integrative strategies have been suggested for other disorders involving altered attentional bias processing, such as obsessive-compulsive and social anxiety disorders ( 24 , 25 ).…”

“…Nonetheless, the standardized processing protocol we applied across all datasets, the strong task effect we observed, and the robustness of our findings to sensitivity analyses suggest we successfully captured domain-level inhibitory control independent of individual task effects. While several meta-analyses have examined inhibitory control in OCD (4,(8)(9)(10)(11)29), our findings go beyond the previous literature by disentangling inhibitory control from broader executive function tasks, which previous studies conflated. Further, our results add to emerging evidence for distinct patterns of lifespan neurodevelopment and aging on neural recruitment during cognitive inhibition and response inhibition (38), underscoring the need to consider developmental stage and task demands when interpreting inhibitory control deficits in OCD.…”

“…Our finding of rich club regions is to a large extent consistent with previous research on whole-brain structural networks in OCD ( Zhou et al, 2020 ). Additionally, the putamen and precentral gyrus were also found to be important hubs in the present study; these regions were also associated with OCD pathomechanism, including in the cortico-striatal circuits in previous studies ( Jang et al, 2010 , Kubota et al, 2019 , Rasgon et al, 2017 , Zhou et al, 2020 ). Moreover, these rich club nodes overlapped with the default mode network (DMN).…”

“…Such an approach may improve not only patient satisfaction but also long-term psychological well-being. Similar integrative strategies have been suggested for other disorders involving altered attentional bias processing, such as obsessive-compulsive and social anxiety disorders ( 24 , 25 ).…”

“…Nonetheless, the standardized processing protocol we applied across all datasets, the strong task effect we observed, and the robustness of our findings to sensitivity analyses suggest we successfully captured domain-level inhibitory control independent of individual task effects. While several meta-analyses have examined inhibitory control in OCD (4,(8)(9)(10)(11)29), our findings go beyond the previous literature by disentangling inhibitory control from broader executive function tasks, which previous studies conflated. Further, our results add to emerging evidence for distinct patterns of lifespan neurodevelopment and aging on neural recruitment during cognitive inhibition and response inhibition (38), underscoring the need to consider developmental stage and task demands when interpreting inhibitory control deficits in OCD.…”