The number of key carcinogenic events can be predicted from cancer incidence

¹

,

²

,

³

2017

Preprint

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…The predicted maximal populational susceptibility varied from 0.0322%, for extracranial and extragonadal germ cell tumours of childhood, to 1.966%, for malignant gonadal germ cell tumours. Overall, the data confirm high heterogeneity in carcinogenesis patterns revealed in the previous study 13 .…”

Section: Results

supporting

confidence: 90%

The Poisson process is the universal law of cancer development: driver mutations accumulate randomly, silently, at constant average rate and for many decades, likely in stem cells

¹

,

²

,

³

2017

Preprint

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…The predicted maximal populational susceptibility varied from 0.0322%, for extracranial and extragonadal germ cell tumours of childhood, to 1.966%, for malignant gonadal germ cell tumours. Overall, the data confirm high heterogeneity in carcinogenesis patterns revealed in the previous study 13 .…”

Section: Results

supporting

confidence: 90%

The Erlang distribution approximates the age distribution of incidence of childhood and young adulthood cancers

¹

,

²

,

³

2021

Peerj

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…The predicted maximal populational susceptibility varied from 0.0322%, for extracranial and extragonadal germ cell tumours of childhood, to 1.966%, for malignant gonadal germ cell tumours. Overall, the data show the same high heterogeneity in carcinogenesis patterns revealed in the previous study ( Belikov, 2017 ).…”

Section: Results

supporting

confidence: 86%

“…We show that the gamma/Erlang distribution is the only distribution that provides close fits for all tested cancers without involvement of negative age values. This result, taken together with our previous findings ( Belikov, 2017 ), suggests that driver accumulation is governed by the Poisson process, both in childhood and in adult cancers. This is consistent with driver mutations that accumulate randomly, silently, at constant average rate and for many decades, likely in stem cells.…”

Section: Introduction

supporting

confidence: 88%

The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs)

Zhang

¹

,

Deng

²

,

Liufu

³

et al. 2024

Elife

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…The number varies in this range depending on the cancer type ( Zhang et al, 2024 ). For comparison, tumorigenesis may require at least 5~10 driver mutations as estimated by various criteria ( Armitage and Doll, 1954 ; Hanahan and Weinberg, 2011 ; Belikov, 2017 ; Martincorena et al, 2017 ; Anandakrishnan et al, 2019 ; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, 2020 ). The results show that there are many more CDNs that have not been discovered.…”

Section: Results

mentioning

confidence: 99%

The Poisson process is the universal law of cancer development: driver mutations accumulate randomly, silently, at constant average rate and for many decades, likely in stem cells

¹

,

²

,

³

2017

Preprint

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…The predicted maximal populational susceptibility varied from 0.0322%, for extracranial and extragonadal germ cell tumours of childhood, to 1.966%, for malignant gonadal germ cell tumours. Overall, the data confirm high heterogeneity in carcinogenesis patterns revealed in the previous study 13 .…”

Section: Results

supporting

confidence: 90%

The Erlang distribution approximates the age distribution of incidence of childhood and young adulthood cancers

¹

,

²

,

³

2021

Peerj

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…The predicted maximal populational susceptibility varied from 0.0322%, for extracranial and extragonadal germ cell tumours of childhood, to 1.966%, for malignant gonadal germ cell tumours. Overall, the data show the same high heterogeneity in carcinogenesis patterns revealed in the previous study ( Belikov, 2017 ).…”

Section: Results

supporting

confidence: 86%

“…We show that the gamma/Erlang distribution is the only distribution that provides close fits for all tested cancers without involvement of negative age values. This result, taken together with our previous findings ( Belikov, 2017 ), suggests that driver accumulation is governed by the Poisson process, both in childhood and in adult cancers. This is consistent with driver mutations that accumulate randomly, silently, at constant average rate and for many decades, likely in stem cells.…”

Section: Introduction

supporting

confidence: 88%

The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs)

Zhang

¹

,

Deng

²

,

Liufu

³

et al. 2024

Elife

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…The number varies in this range depending on the cancer type ( Zhang et al, 2024 ). For comparison, tumorigenesis may require at least 5~10 driver mutations as estimated by various criteria ( Armitage and Doll, 1954 ; Hanahan and Weinberg, 2011 ; Belikov, 2017 ; Martincorena et al, 2017 ; Anandakrishnan et al, 2019 ; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, 2020 ). The results show that there are many more CDNs that have not been discovered.…”

Section: Results

mentioning

confidence: 99%

The Poisson process is the universal law of cancer development: driver mutations accumulate randomly, silently, at constant average rate and for many decades, likely in stem cells

¹

,

²

,

³

2017

Preprint

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…The predicted maximal populational susceptibility varied from 0.0322%, for extracranial and extragonadal germ cell tumours of childhood, to 1.966%, for malignant gonadal germ cell tumours. Overall, the data confirm high heterogeneity in carcinogenesis patterns revealed in the previous study 13 .…”

Section: Results

supporting

confidence: 90%

The Erlang distribution approximates the age distribution of incidence of childhood and young adulthood cancers

¹

,

²

,

³

2021

Peerj

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…The predicted maximal populational susceptibility varied from 0.0322%, for extracranial and extragonadal germ cell tumours of childhood, to 1.966%, for malignant gonadal germ cell tumours. Overall, the data show the same high heterogeneity in carcinogenesis patterns revealed in the previous study ( Belikov, 2017 ).…”

Section: Results

supporting

confidence: 86%

“…We show that the gamma/Erlang distribution is the only distribution that provides close fits for all tested cancers without involvement of negative age values. This result, taken together with our previous findings ( Belikov, 2017 ), suggests that driver accumulation is governed by the Poisson process, both in childhood and in adult cancers. This is consistent with driver mutations that accumulate randomly, silently, at constant average rate and for many decades, likely in stem cells.…”

Section: Introduction

supporting

confidence: 88%

The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs)

Zhang

¹

,

Deng

²

,

Liufu

³

et al. 2024

Elife

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…The number varies in this range depending on the cancer type ( Zhang et al, 2024 ). For comparison, tumorigenesis may require at least 5~10 driver mutations as estimated by various criteria ( Armitage and Doll, 1954 ; Hanahan and Weinberg, 2011 ; Belikov, 2017 ; Martincorena et al, 2017 ; Anandakrishnan et al, 2019 ; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, 2020 ). The results show that there are many more CDNs that have not been discovered.…”

Section: Results

mentioning

confidence: 99%