2017
Mesenchymal stem cells: A new platform for targeting suicide genes in cancer
Abstract: One of the important strategies for the treatment of cancer is gene therapy which has the potential to exclusively eradicate malignant cells, without any damage to the normal tissues. Gene-directed enzyme prodrug therapy (GDEPT) is a two-step gene therapy approach, where a suicide gene is directed to tumor cells. The gene encodes an enzyme that expressed intracellularly where it is able to convert a prodrug into cytotoxic metabolites. Various delivery systems have been developed to achieve the appropriate leve…
Search citation statements
Paper Sections
Select...
75
18
3
1
Citation Types
0
45
0
1
Year Published
Range
2017
2026
Publication Types
Select...
73
20
2
Relationship
7
88
Authors
Journals
Cited by 95 publications
(46 citation statements)
References 190 publications
0
45
0
1
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…3 d, Additional file 10 ) [ 58 ]. Furthermore, for AD-MSCs to serve as cancer targeting vehicles, the processes used to modify them must not change their capacity for migration and homing [ 16 , 59 ]. Despite the high transfection efficiency, the tumour tropism of the CD::UPRT::GFP_AD-MSCs was comparable to the unmodified MSCs in the presence of cancer cells in vitro (Fig.…”
Section: Results
mentioning
confidence: 99%