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Review
. 2019:1895:1-9.
doi: 10.1007/978-1-4939-8922-5_1.

Origins of Suicide Gene Therapy

Nejat Düzgüneş  1
Affiliations
Review

Origins of Suicide Gene Therapy

Nejat Düzgüneş. Methods Mol Biol. 2019.

Abstract

"Tumor chemosensitivity" can be achieved by the expression of the herpes simplex virus thymidine kinase gene in cells, followed by the conversion of the "prodrug" ganciclovir into the therapeutic drug inside the cells. This system presaged other combinations of suicide genes and prodrugs, including cytosine deaminase/5-fluorocytosine, purine nucleoside phosphorylase/6-methylpurine deoxyriboside, and horseradish peroxidase/indole-3-acetic acid.

Keywords: Cytosine deaminase; Herpes simplex virus thymidine kinase; Horseradish peroxidase; Prodrug; Purine nucleoside phosphorylase; Suicide gene therapy.

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