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. 2008 Aug;40(4):175-9.
doi: 10.4103/0253-7613.43165.

Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice

Dinesh Dhingra  1 , Vaibhav Kumar
Affiliations

Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice

Dinesh Dhingra et al. Indian J Pharmacol. 2008 Aug.

Abstract

Objectives: The present study was undertaken to investigate the effect of the ethanolic extract of Allium sativum L. (Family: Lilliaceae), commonly known as garlic, on depression in mice.

Materials and methods: Ethanolic extract of garlic (25, 50 and 100 mg/kg) was administered orally for 14 successive days to young Swiss albino mice of either sex and antidepressant-like activity was evaluated employing tail suspension test (TST) and forced swim test (FST). The efficacy of the extract was compared with standard antidepressant drugs like fluoxetine and imipramine. The mechanism of action of the extract was investigated by co-administration of prazosin (alpha1-adrenoceptor antagonist), sulpiride (selective D2-receptor antagonist), baclofen (GABA(B) agonist) and p-CPA (serotonin antagonist) separately with the extract and by studying the effect of the extract on brain MAO-A and MAO-B levels.

Results: Garlic extract (25, 50 and 100 mg/kg) significantly decreased immobility time in a dose-dependent manner in both TST and FST, indicating significant antidepressant-like activity. The efficacy of the extract was found to be comparable to fluoxetine (20 mg/kg p.o.) and imipramine (15 mg/kg p.o.) in both TST and FST. The extract did not show any significant effect on the locomotor activity of the mice. Prazosin, sulpiride, baclofen and p-CPA significantly attenuated the extract-induced antidepressant-like effect in TST. Garlic extract (100 mg/kg) administered orally for 14 successive days significantly decreased brain MAO-A and MAO-B levels, as compared to the control group.

Conclusion: Garlic extract showed significant antidepressant-like activity probably by inhibiting MAO-A and MAO-B levels and through interaction with adrenergic, dopaminergic, serotonergic and GABAergic systems.

Keywords: Allium sativum; depression; forced swim test; monoamine oxidase; tail suspension test.

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References

    1. Gold PW, Goodwin FK, Chrousus GP. Clinical and biochemical manifestations of depression: Relation to the neurobiology of stress: Part 1. N Engl J Med. 1988;319:348–53. - PubMed
    1. Leonard BE. Evidence for a biochemical lesion in depression. J Clin Psychiatry. 2000;61:12–7. - PubMed
    1. Nutt DJ. The neuropharmacology of serotonin and noradrenaline in depression. Int Clin Psychopharmacol. 2002;17:S1–12. - PubMed
    1. Esel E, Kose K, Turan MT, Basturk M, Sofuoglu S, Aslan SS, et al. Monoamine oxidase-B activity in alcohol withdrawal of smoker: Is there any relationship with aggressiveness. Alcohol Alcoholism. 2002;37:272–6. - PubMed
    1. Pan SL, Xie J, Qian FG, Wang J, Shao YC. Yao Xue Xue Bao. Vol. 40. DC: 2005. Antidepressant amides from Piper laetispicum C; pp. 355–7. - PubMed