Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Summer;40(2):327-61.
doi: 10.1007/s10739-006-9105-5.

Panpsychic organicism: Sewall Wright's philosophy for understanding complex genetic systems

Affiliations

Panpsychic organicism: Sewall Wright's philosophy for understanding complex genetic systems

David M Steffes. J Hist Biol. 2007 Summer.

Abstract

Sewall Wright first encountered the complex systems characteristic of gene combinations while a graduate student at Harvard's Bussey Institute from 1912 to 1915. In Mendelian breeding experiments, Wright observed a hierarchical dependence of the organism's phenotype on dynamic networks of genetic interaction and organization. An animal's physical traits, and thus its autonomy from surrounding environmental constraints, depended greatly on how genes behaved in certain combinations. Wright recognized that while genes are the material determinants of the animal phenotype, operating with great regularity, the special nature of genetic systems contributes to the animal phenotype a degree of spontaneity and novelty, creating unpredictable trait variations by virtue of gene interactions. As a result of his experimentation, as well as his keen interest in the philosophical literature of his day, Wright was inspired to see genetic systems as conscious, living organisms in their own right. Moreover, he decided that since genetic systems maintain ordered stability and cause unpredictable novelty in their organic wholes (the animal phenotype), it would be necessary for biologists to integrate techniques for studying causally ordered phenomena (experimental method) and chance phenomena (correlation method). From 1914 to 1921 Wright developed his "method of path coefficient" (or "path analysis"), a new procedure drawing from both laboratory experimentation and statistical correlation in order to analyze the relative influence of specific genetic interactions on phenotype variation. In this paper I aim to show how Wright's philosophy for understanding complex genetic systems (panpsychic organicism) logically motivated his 1914-1921 design of path analysis.

PubMed Disclaimer

References

    1. Perspect Biol Med. 1982 Winter;25(2):279-94 - PubMed
    1. Osiris. 1987;3:165-92 - PubMed
    1. Science. 1959 Oct 16;130(3381):959-65 - PubMed
    1. J Hist Biol. 1975 Spring;8(1):85-93 - PubMed
    1. Proc Natl Acad Sci U S A. 1920 Jun;6(6):320-32 - PubMed

Personal name as subject