High-Intensity Aerobic Exercise Increases 'Brain-Derived Neurotrophic Factor'

📖 Literature Information and Abstract Translation

The relationship between exercise and brain-derived neurotrophic factor in stroke survivors: A systematic review and meta-analysis.

[Background/Objective] Brain-derived neurotrophic factor (BDNF) is a biomarker of neuroplasticity that leads to improved functional outcomes after a stroke. While there is preliminary evidence suggesting that concentrations may increase after exercise in stroke patients, it is unclear how exercise parameters affect BDNF concentrations.

[Methods-Results] This systematic review and meta-analysis searched seven electronic databases. It targeted experimental or observational studies that measured changes in BDNF concentrations after exercise in people after a stroke. Data such as study characteristics, participants, interventions, and outcomes were extracted. Several fixed-effect and random-effect meta-analyses were performed.

[Results] A total of 17 studies including 687 participants met the eligibility criteria (6 randomized trials).Significant improvements in BDNF concentrations were observed after a single session (mean difference, 2.49 ng/mL; [95% CI, 1.10-3.88]) and high-intensity aerobic exercise programs (mean difference, 3.42 ng/mL; [95% CI, 1.92-4.92]). were observed.

[Conclusion] High-intensity aerobic exercise increases circulating BDNF concentrations and may contribute to increased neuroplasticity.

🌱 So What?: What did I find interesting?

It was something I had been vaguely feeling for a while, but reading this paper made a certain concept feel crystallized.

What does this mean?
Many physical therapists and medical professionals think,'It's cool to be able to explain why you chose this intervention now, what will improve because of this intervention and why, and then actually achieve those results.'In other words, it is considered good to clearly identify the target keyhole (evaluation-problem extraction), create a key (intervention), and cause improvement.
For example, suppose a Trendelenburg gait appears during walking, and there were no problems with the gluteus medius or other impairment-level factors.

And so on.
In the field analogy, this is the act of trying to grow a specific target crop.
But there is something important here.
What happens if the soil is too hard or lacks nutrients?
Naturally, it won't grow.
Just as gluconeogenesis occurs if an athlete does a lot of muscle training but is malnourished, even if there is a demand for growth, if the soil of 'nutrition' has not been tilled, there will be no fruit.

That is where the relationship between growth in nerves and BDNF comes in.
This has a relationship similar to that of specific crops and soil.
Even if a certain nerve cell has a demand for growth, if there is no nutrition called BDNF, growth is unlikely to occur.
In other words, it is a 'prerequisite' for growth.
Just as albumin is a prerequisite for muscle hypertrophy.

And it is 'high-intensity aerobic exercise' that tills the soil of BDNF.
There is no intention to create a specific crop there yet.
Rather, there shouldn't be.
First, till the soil, then plant the crops.
In rehabilitation, I want to follow that order.
In the example from earlier,
① Increase BDNF through high-intensity aerobic exercise (till the soil)
② Step exercises to improve Trendelenburg gait (plant the crops)
Through this ①→②, the effect of ② is guaranteed.
From now on, I will ask myself.

Unless contraindicated, high-intensity aerobic exercise might be good as a default for all patients.

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