Why Do Diseases Occur? Series 7 - Let's Cure Type 2 Diabetes! Part 1 -
Diabetes is one of the most common diseases involving hormones.
In Type 1 diabetes, insulin itself is lacking because insulin-secreting cells have decreased, but in many cases of Type 2 diabetes, insulin-secreting cells remain and still have the capacity to secrete insulin.
So, this time, we are going to talk about how to cure Type 2 diabetes!
Why is blood sugar high even though insulin can be secreted? There are mainly two reasons!
1. There is a delay between the rise in blood sugar and the secretion of insulin.
2. Insulin is not working effectively.
This time, I will address the insulin secretion mechanism in point 1, and next time, I will explain the effectiveness of insulin.
As shown in the figure below, in Type 2 diabetes, there is often a delay between the rise in blood sugar and the secretion of insulin. Because insulin secretion is delayed, blood sugar levels rise significantly at first. Even if blood sugar levels drop due to the delayed secretion of insulin, the blood sugar levels then drop too low because the insulin is slow to recede. It is not uncommon to have a condition where you have 'diabetes but also hypoglycemia,' even without using medication.
When blood sugar levels drop too low, a very strong sense of hunger occurs, and you want to eat carbohydrates or sugars. This leads to a vicious cycle where blood sugar levels repeatedly rise and fall, and visceral fat also increases. Many people have said that when they stopped eating rice and switched to foods that stabilize blood sugar, such as meat and fish, their hunger disappeared more than before.
For insulin to be released at the right time, it is important to replenish the nutrients involved in secretion. In the pancreatic beta cells, when blood sugar levels rise, insulin is secreted in the following order:
1. The amount of glucose taken in by glucose transporters (GLUT2) increases.
2. Glucose is metabolized, and energy (ATP) production increases.
3. The increase in ATP causes potassium channels to open.
4. The intracellular potential changes, and calcium channels open.
5. Changes in intracellular calcium concentration cause granules containing insulin to be released.
A deficiency in B vitamins slows down the reaction in step 2, while a deficiency in calcium or magnesium slows down the reaction in step 5. Furthermore, zinc deficiency causes problems with insulin secretion. Therefore, by taking plenty of B vitamins, calcium, magnesium, and zinc, there is a possibility that you can restore the body's original regulatory mechanism.
Next time, let's think about how to improve the effectiveness of insulin.
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