🧡 What is Adult-Onset Still's Disease? - Everything About Symptoms, Diagnosis, Treatment, and Differential Diagnosis -
✅ Table of Contents
What kind of disease is Adult-Onset Still's Disease?
Main Symptoms
Difficulty and Key Points of Diagnosis
About Treatment Methods
Distinguishing from Other Diseases (Differential Diagnosis)
Summary: Living with Still's Disease
Citations and Reference Papers
Tag List
1. What kind of disease is Adult-Onset Still's Disease?
Adult-Onset Still's Disease (AOSD) is an autoinflammatory disease that mainly causes severe inflammation throughout the body. It is a disease caused by immune system runaway, not by viruses or bacteria, and the exact cause is not yet known.
It often occurs in young adults to middle-aged people, and is characterized by sudden high fever, joint pain, and skin rashes. In Japan, it is designated as an intractable disease (specified disease), and early detection and treatment are important.
2. Main Symptoms
Still's disease has a variety of symptoms and is characterized by being easily mistaken for other diseases. The main symptoms are as follows:
3. Difficulty and Key Points of Diagnosis
For Still's disease, there is no specific test that can confirm it with certainty. Therefore, it is carefully diagnosed using the following methods.
✔️ Key Points for Diagnosis
The presence of high fever, rash, and arthritis
Abnormalities in inflammatory markers (CRP, ferritin, etc.)
Excluding other diseases (infections, cancer, rheumatism, etc.)
🧪 Tests Used
Blood tests (white blood cell count, CRP, ferritin, etc.)
X-rays and CT scans (to check joints and internal organs)
Checks for infections (influenza, tuberculosis, hepatitis, etc.)
📘 Diagnostic Criteria (e.g., Yamaguchi criteria)
The "Yamaguchi criteria," proposed in 1992, are commonly used for the diagnosis of AOSD.
Reference: Yamaguchi et al., "Preliminary criteria for classification of adult Still's disease", J Rheumatol. 1992
4. About Treatment
The goal of treatment is to "suppress immune system overactivity and control symptoms."
🥇 Main Therapeutic Drugs
5. Distinguishing from Other Diseases (Differential Diagnosis)
Because Still's disease has symptoms that are very similar to other diseases, it is necessary to rule out the following conditions during diagnosis.
6. Summary: Living with Still's Disease
Adult-onset Still's disease is "rare" but is a condition that is "easily overlooked."
If you have persistent unexplained high fever, joint pain, or rashes, see a rheumatologist/collagen disease specialist promptly.
Many therapeutic drugs are being developed, and with proper diagnosis and treatment, symptoms can be suppressed.
Differential diagnosis is extremely important, so do not rush and make sure to undergo thorough testing.
7. Citations and Reference English Papers
Yamaguchi M, et al. Preliminary criteria for classification of adult Still's disease. J Rheumatol. 1992.
https://pubmed.ncbi.nlm.nih.gov/1578452/Efthimiou P, et al. Adult-onset Still's disease: pathogenesis, clinical manifestations, and new treatment options. Ann Rheum Dis. 2006.
https://pubmed.ncbi.nlm.nih.gov/16339290/Gerfaud-Valentin M, et al. Adult-onset Still’s disease. Autoimmun Rev. 2014.
https://pubmed.ncbi.nlm.nih.gov/24508531/
8. List of Tags
#スティル病 #成人発症スティル病 #高熱 #関節痛 #リウマチ #膠原病 #難病 #自己炎症性疾患 #IVIG #生物学的製剤 #診断の難しさ #早期発見 #Yamaguchi基準