Bayesian Adaptive Methods for Clinical TrialsAlready popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer's disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adapti |
Contents
Statistical approaches for clinical trials | 1 |
Basics of Bayesian inference | 19 |
Phase I studies | 87 |
Phase II studies | 137 |
Phase III studies | 193 |
Special topics | 249 |
| 281 | |
Back cover | 297 |
Other editions - View all
Bayesian Adaptive Methods for Clinical Trials Scott M. Berry,Bradley P. Carlin,J. Jack Lee,Peter Muller Limited preview - 2010 |
Bayesian Adaptive Methods for Clinical Trials Scott M. Berry,Bradley P. Carlin,J. Jack Lee,Peter Muller No preview available - 2010 |
Bayesian Adaptive Methods for Clinical Trials Bradley P. Carlin,J. Jack Lee,Scott M. Berry,Peter Muller No preview available - 2024 |
Common terms and phrases
accrual rate adaptive design adaptive randomization algorithm assigned assume Bayes Bayesian approach Bayesian methods binary calculation cancer clinical trials cohort computing confirmatory trial covariates credible interval decision defined denote density dose escalation dose level drug early stopping efficacy enrolled estimate evaluate example Figure final FOLFOX frequentist Gibbs sampler hierarchical model hyperprior implementation inference likelihood Likelihood Principle maximum sample MCMC mean sample multiple Nmax null hypothesis number of patients observed operating characteristics outcome p-value parameters phase II trial posterior distribution posterior mean posterior probability power prior predictive distribution predictive probability prior distribution probability of success regulatory response rate scenario seamless phase selected simulation truth specific Stage standard statistical Step stopping for futility stopping rule subgroup subjects Table Thall therapy treated treatment arm trial design tumor Type I error typically updated WinBUGS δυ