Chlorogenic acid 是 Lonicera japonica Thunb 中的主要酚类化合物 | MedChemExpress (MCE)

Chlorogenic acid

中文名：绿原酸

CAS：327-97-9

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Chlorogenic acid 是 Lonicera japonica Thunb 中的主要酚类化合物。它具有多种重要的治疗作用，例如抗氧化活性、抗菌、保肝、心脏保护、抗炎、解热、神经保护、抗肥胖、抗病毒、抗微生物、抗高血压。

体外：Chlorogenic acid (10 μM, 16 h) 可降低 CoCl2 诱导的缺氧 A549 细胞中的 HIF-1α 蛋白水平，但不影响 HIF-1α mRNA 水平[1]。 Chlorogenic acid (10 μM，24 h) 抑制缺氧诱导的 HUVEC 细胞迁移、侵袭和血管内皮细胞管形成[1]。 Chlorogenic acid (25, 50 μM, 24 h) 抑制 Huh7 细胞增殖，并减少入侵和迁移细胞的数量[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Chlorogenic acid (10 μM, 皮下注射) 通过抑制 AKT 激活来抑制 C57BL/6J 小鼠中 VEGF (200 ng/mL) 诱导的血管生成 (基质胶塞测定)[1]。 Chlorogenic acid (10-100 mg/kg，口服) 对大鼠实验性反流性食管炎具有保护作用[3]。 Chlorogenic acid (10 mg/kg，静脉注射) 可预防 LPS 中毒的 C57BL/6 小鼠的内毒素死亡和诱导的 TNF-α 释放，并改善 LPS/GalN 攻击小鼠的急性肝损伤[2] . Chlorogenic acid (腹腔注射，25-200 mg/kg) 可抑制接种 Huh7 或 H446 细胞的 NOD/SCID 小鼠的肿瘤生长[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Experimental reflux esophagitis (RE) in rats[1] Dosage: 10, 30, 100 mg/kg Administration: p.o. Result: Reduced esophageal lipid peroxidation (marker: MDA) and increased the reduced glutathione/oxidized glutathione ratio. Inhibited the increases in the serum level of TNF-α, and expressions of iNOS and COX-2 protein. Animal Model: LPS/GalN-challenged mice[2] Dosage: 10 mg/kg Administration: i.v. Result: Increased survival rates of LPS/GalN-intoxicated mice. Inhibited LPS/GalN-induced phosphorylation of NF-κB p65 or c-Jun, without affecting p-IRF3 levels in the liver lobules. Clinical Trial

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参考文献：

[1]. Park JJ, et al. Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1α/AKT pathway. Cell Oncol (Dordr). 2015 Jan 6.
[2]. Park SH, et al. IRAK4 as a Molecular Target in the Amelioration of Innate Immunity-Related Endotoxic Shock and Acute Liver Injury by Chlorogenic Acid. J Immunol. 2015 Feb 1;194(3):1122-30.
[3]. Kang JW, et al. Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats. Biomol Ther (Seoul). 2014 Sep;22(5):420-5.
[4]. Huang S, et al. Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation. Theranostics. 2019 Sep 19;9(23):6745-6763.